Binding to four‐way junction DNA: a common property of architectural proteins?
Binding to four‐way junction DNA: a common property of architectural proteins?
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DOI：
10.1096/fasebj.12.6.421
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发表时间：
1998-04
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影响因子：
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通讯作者：
J. Zlatanova;K. Holde
中科院分区：
文献类型：
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作者：
J. Zlatanova;K. Holde
在体外可以被证明与四向（Holliday）连接DNA强烈结合的蛋白质不仅包括明显的候选者，如参与重组的酶，还包括一组非常多样化的看似不相关的蛋白质。这些蛋白包括HMG1盒蛋白、HMGI - Y家族成员、带翼螺旋蛋白（包括连接体组蛋白）、SWI/SNF复合物以及一些完全不相关的原核蛋白。这些蛋白质似乎都倾向于与弯曲的DNA结合，结合时弯曲DNA，和/或优先与DNA交叉点相互作用。因此，它们似乎主要是建筑蛋白，尽管有些（如SWI/SNF复合体）也具有非常特定的功能角色。也许是因为它们结合或促进特定DNA结构的形成，四向连接结合蛋白在细胞功能中经常是可互换的。此外，由于一种给定的结构可以被许多不同的蛋白质基序识别，因此表面上不相关的蛋白质可以落入这样一个单一的功能类也就不足为奇了。-Zlatanova， J., van Holde， K.与四向连接DNA的结合：建筑蛋白的共同特性？中华医学杂志，12,421-431 （1998）
Proteins that can be shown to strongly bind in vitro to the four‐way (Holliday) junction DNA include not only the obvious candidates such as enzymes involved in recombination, but also a remarkably diverse group of seemingly unrelated proteins. These include the HMG1 box proteins, members of the HMGI‐Y family, winged helix proteins (including linker histones), the SWI/SNF complex, and some totally unrelated prokaryotic proteins. What these proteins seem to share is a propensity to bind to bent DNA, to bend DNA upon binding, and/or to preferentially interact with DNA crossings. Thus, they appear to be, in the main, architectural proteins, although some (like the SWI/SNF complex) have very specific functional roles as well. Perhaps because they bind to or promote the formation of particular DNA structures, the four‐way junction binding proteins are frequently interchangeable in cellular function. Furthermore, since a given kind of structure can be recognized by many different protein motifs, it is not surprising that apparently unrelated proteins can fall into such a single functional class.—Zlatanova, J., van Holde, K. Binding to four‐way junction DNA: a common property of architectural proteins? FASEB J. 12, 421–431 (1998)