Recent advances in the molecular epidemiology and control of human enterovirus 71 infection
Recent advances in the molecular epidemiology and control of human enterovirus 71 infection
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DOI：
10.1016/j.coviro.2012.02.009
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发表时间：
2012-04-01
影响因子：
5.9
通讯作者：
McMinn, Peter C.
中科院分区：
文献类型：
--
作者：
McMinn, Peter C.
人类肠道病毒71型（HEV71）在过去的15年中已成为东南亚病毒性脑炎的重要原因。自1997年以来，已经观察到HEV71的流行活动和地方性循环增加的模式，并且与新的遗传谱系的定期出现有关。虽然HEV71循环增加的原因仍然未知，但越来越多的证据表明重组事件可能会推动新遗传谱系的进化。预防HEV71流行可能需要开发有效的疫苗。幸运的是，最近报道了几种EV71候选疫苗，其中几种已在动物模型中显示有效，并于2010年开始临床试验。此外，对HEV71感染和毒力的分子基础的正在进行的研究已经为开发减毒活疫苗的新方法指明了方向。
Human enterovirus 71 (HEV71) has emerged as an important cause of viral encephalitis in the Southeast Asia over the past 15 years. A pattern of increased epidemic activity and endemic circulation of HEV71 has been observed since 1997 and is associated with the regular emergence of new genetic lineages. Although the reason for this increase in HEV71 circulation remains unknown, evidence is accumulating that recombination events may drive the evolution of new genetic lineages. Prevention of HEV71 epidemics is likely to require the development of an effective vaccine. Fortunately, several candidate EV71 vaccines have recently been reported, several of which have been shown to be effective in animal models and commenced clinical trial in 2010. Furthermore, ongoing investigations into the molecular basis of HEV71 infection and virulence have pointed the way towards novel approaches to live attenuated vaccine development.