Cell Death in AMD: The Rationale for Targeting Fas.
Cell Death in AMD: The Rationale for Targeting Fas.
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DOI：
10.3390/jcm11030592
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发表时间：
2022-01-25
影响因子：
3.9
通讯作者：
Handa JT
中科院分区：
文献类型：
--
作者：
Zacks DN;Kocab AJ;Choi JJ;Gregory-Ksander MS;Cano M;Handa JT
视网膜相关性黄斑变性（AMD）是发达国家不可逆失明的主要原因。虽然在治疗新生血管（“湿”）形式的疾病方面已经取得了很大进展，但仍然非常需要预防与干性萎缩性AMD的晚期形式相关的视力丧失的疗法。在这种萎缩形式中，视网膜色素上皮（RPE）和光感受器细胞死亡是视力丧失的最终原因。本文就AMD的细胞死亡途径及其与RPE和视网膜细胞死亡的关系作一综述。我们回顾了支持通过抑制Fas受体来靶向程序性细胞死亡的数据，作为一种新的方法来保护这些结构，并且这种效果是通过抑制经典死亡途径激活和减少相关的炎症反应来实现的。这些数据奠定了基础，目前的临床策略，针对Fas通路在这种毁灭性的疾病。
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the developed world. While great advances have been made in the treatment of the neovascular (“wet”) form of the disease, there is still a significant need for therapies that prevent the vision loss associated with the advanced forms of dry, atrophic AMD. In this atrophic form, retinal pigment epithelial (RPE) and photoreceptor cell death is the ultimate cause of vision loss. In this review, we summarize the cell death pathways and their relation to RPE and retinal cell death in AMD. We review the data that support targeting programmed cell death through inhibition of the Fas receptor as a novel approach to preserve these structures and that this effect results from inhibiting both canonical death pathway activation and reducing the associated inflammatory response. These data lay the groundwork for current clinical strategies targeting the Fas pathway in this devastating disease.
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