Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
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DOI：
10.3390/biomedicines8020018
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发表时间：
2020-02-01
期刊：
影响因子：
4.7
通讯作者：
Fujino, Hidemi
中科院分区：
文献类型：
--
作者：
Li, Xing;Matsumoto, Tomohiro;Fujino, Hidemi
紫外线(UV)导致皮肤光老化，其特征是变厚、皱纹、色素沉着和干燥。虾青素(AST)是从雨生红球藻中分离出来的一种酮类胡萝卜素，由于其对皮肤健康和紫外线防护的可能作用，已被广泛研究。此外，天冬氨酸转氨酶可减轻骨骼肌中增加的活性氧簇(ROS)生成和毛细血管退化。在这项研究中，我们研究了AST是否可以防止紫外线诱导的光老化和减少HR-1无毛小鼠皮肤的毛细血管退化。紫外线可诱导HR-1无毛小鼠真皮中的皱纹形成、表皮增厚和毛细血管退化。给予AST可减少紫外线诱导的皱纹形成和皮肤增厚，增加皮肤中的胶原纤维。补充AST还可以抑制ROS的产生，减少皱纹的形成，减少表皮增厚，并增加皮肤中的毛细血管密度。我们还发现，皱纹的形成与毛细血管的密度呈负相关。还观察到皮肤的光老化和毛细血管退化之间的关系。这些结果表明，AST对紫外线照射引起的光老化有保护作用，其抑制光老化的作用可能与减少皮肤毛细血管退缩有关。
Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin.