Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection.
Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection.
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DOI：
10.1159/000455857
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发表时间：
2017
影响因子：
5.3
通讯作者：
Kazmierczak BI
中科院分区：
文献类型：
--
作者：
Lin CK;Kazmierczak BI
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa exploits failures of barrier defense and innate immunity to cause acute infections at a range of anatomic sites. We review the defense mechanisms that normally protect against P. aeruginosa pulmonary infection, as well as the bacterial products and activities that trigger their activation. Innate immune recognition of P. aeruginosa is critical for pathogen clearance; nonetheless, inflammation is also associated with pathogen persistence and poor host outcomes. We describe P. aeruginosa adaptations that improve this pathogen’s fitness in the inflamed airway, and briefly discuss strategies to manipulate inflammation to host benefit. Such adjunct therapies may become increasingly important in the treatment of acute and chronic infections caused by this multi-drug resistant pathogen.
