Subcortical dementia revisited: Similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA)
Subcortical dementia revisited: Similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA)
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DOI：
10.1080/13554790590962997
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发表时间：
2005-08-01
期刊：
影响因子：
0.8
通讯作者：
Hodges, JR
中科院分区：
文献类型：
--
作者：
Bak, TH;Crawford, LM;Hodges, JR
为了研究与帕金森相关的三种主要的皮质下痴呆疾病之间认知功能的异同，我们使用两种不同的认知筛查测试，比较了39例进行性核上性麻痹（PSP）、26例多系统萎缩（MSA）和25例皮质基底变性（CBD）患者与30例经典皮质性痴呆、阿尔茨海默病（AD）患者的认知表现：痴呆评定量表（DRS）和阿登布鲁克认知测验（ACE）。ACE和DRS亚测试的认知特征可以区分皮层下疾病和AD。所有帕金森综合症的特征都是语言流畅性，尤其是字母流畅性的不成比例的损害。然而，这三种疾病在语言、记忆和视觉空间损害的程度上有所不同。我们的结论是，PSP、MSA和CBD之间的异同可以通过一个简短的、临床适用的认知筛查测试来检测。认知障碍的模式可能反映了不同的病理分布，特别是PSP和CBD的皮质受累程度更高。
To examine the similarities and differences in cognitive function between three predominantly subcortical dementing disorders associated with parkinsonism we compared the profiles of cognitive performance in 39 patients with Progressive Supranuclear Palsy ( PSP), 26 patients with Multiple System Atrophy ( MSA) and 25 with Corticobasal Degeneration ( CBD) with those of 30 patients with classic cortical dementia, Alzheimer's Disease ( AD), using two different cognitive screening tests: Dementia Rating Scale ( DRS) and Addenbrooke's Cognitive Examination ( ACE). The cognitive profile on ACE and DRS subtests distinguished subcortical diseases from each other as well as from AD. All parkinsonian syndromes were characterized by a disproportionate impairment in verbal fluency, particularly letter fluency. The three diseases differed, however, in the degree of language, memory and visuospatial impairment. We conclude that similarities, as well as differences, between PSP, MSA and CBD can be detected using a brief, clinically applicable cognitive screening test. The pattern of cognitive impairment is likely to reflect a different distribution of pathology, in particular a higher degree of cortical involvement in PSP and CBD.