Methods of assessment of zinc status in humans: a systematic review
Methods of assessment of zinc status in humans: a systematic review
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DOI：
10.3945/ajcn.2009.27230g
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发表时间：
2009-06-01
影响因子：
7.1
通讯作者：
Decsi, Tamas
中科院分区：
文献类型：
--
作者：
Lowe, Nicola M.;Fekete, Katalin;Decsi, Tamas
背景：锌是人体健康必需的微量营养素，具有多种结构和生物化学作用。寻找一个可靠的，敏感的，和具体的锌状态指数一直是相当多的研究的主题，这导致了一些潜在的有用的生物标志物的鉴定。目的：目的是评估锌状态的生物标志物在human.Design中的有用性：方法包括使用奥维德MEDLINE，EMBASE（奥维德）和科克伦图书馆CENTRAL数据库的结构化搜索策略;正式的纳入和排除标准;数据提取到Access数据库;质量和有效性评估;和荟萃分析。在成人、女性、男性、孕妇和哺乳期妇女、老年人以及处于低和中度基线锌状态的人中，血浆锌浓度以剂量依赖性方式对饮食控制作出反应。尿锌排泄对总体和所有亚组的锌状态有反应，这些亚组有足够的数据。发锌浓度也有反应，但亚组分析的研究不足。血小板，多形核细胞，单核细胞，红细胞锌浓度和碱性磷酸酶活性没有出现有效的生物标志物锌status.Conclusions：本系统评价证实，在健康个体，血浆，尿，头发锌是可靠的生物标志物锌状态。需要使用这些生物标志物进行进一步的高质量研究，特别是在数据有限的婴儿，青少年和移民人群中。还需要进行研究，以充分评估一系列其他潜在的锌生物标志物。美国临床营养杂志2009; 89（增刊）：2040 S-51 S。
Background: Zinc is an essential micronutrient for human health and has numerous structural and biochemical roles. The search for a reliable, sensitive, and specific index of zinc status has been the subject of considerable research, which has resulted in the identification of a number of potentially useful biomarkers.Objective: The objective was to assess the usefulness of biomarkers of zinc status in humans.Design: The methods included a structured search strategy using Ovid MEDLINE, EMBASE (Ovid), and the Cochrane Library CENTRAL databases; formal inclusion and exclusion criteria; data extraction into an Access database; quality and validity assessment; and meta-analysis.Results: Data on 32 potential biomarkers from 46 publications were analyzed. Plasma zinc concentration responded in a dose-dependent manner to dietary manipulation in adults, women, men, pregnant and lactating women, the elderly, and those at low and moderate baseline zinc status. Urinary zinc excretion responded to zinc status overall and in all subgroups for which there were sufficient data. Hair zinc concentration also responded, but there were insufficient studies for subgroup analysis. Platelet, polymorphonuclear cell, mononuclear cell, and erythrocyte zinc concentration and alkaline phosphatase activity did not appear to be effective biomarkers of zinc status.Conclusions: This systematic review confirms that in healthy individuals, plasma, urinary, and hair zinc are reliable biomarkers of zinc status. Further high-quality studies using these biomarkers are required, particularly in infants, adolescents, and immigrant population groups for whom there are limited data. Studies are also required to fully assess a range of additional potential zinc biomarkers. Am J Clin Nutr 2009; 89(suppl): 2040S-51S.