Mechanism of the pleiotropic effects of the short-ear mutant gene in the mouse.
Mechanism of the pleiotropic effects of the short-ear mutant gene in the mouse.
复制标题
小鼠短耳突变基因的多效性作用机制。
DOI：
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发表时间：
1968
期刊：
影响因子：
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通讯作者：
M. C. Green
中科院分区：
文献类型：
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作者：
M. C. Green
隐性突变基因短耳(Se)降低了前软骨细胞的增殖速度，导致骨骼尺寸缩小，并伴有许多小缺陷。它还可以降低骨折愈合过程中骨痂细胞的增殖率。在这项研究中，硒被证明不影响肝、胸腺或结缔组织的再生率。
短耳小鼠存在许多软组织的解剖异常，包括左性腺内侧移位、右肾动脉腹侧移位、输尿管积水和肾积水、肝脏腹面巨细胞肉芽肿，以及某些遗传背景下肺囊肿的发生率增加。年轻的Se/Se小鼠通常有神经肌肉尾部的波浪形。在杂合子(+/se)条件下，该基因导致骨骼尺寸略有减小，输尿管积水、肝脏病变、肺囊肿和波尾的发生率略有增加。结果表明，从妊娠11天开始，内脏出现拥挤，这可能是左性腺、右肾动脉和输尿管异常的原因，也可能是肝脏肉芽肿的原因之一。拥挤的原因可能是骨骼生长缓慢，导致体腔太小，无法容纳正常大小的内脏质量。目前还不清楚拥挤是对肝脏损害的充分解释，也不清楚它是否解释了硒对肺囊肿频率或尾巴波浪度的影响。
The recessive mutant gene short-ear (se) reduces the rate of proliferation of precartilage cells, producing a skeleton of reduced size with numerous small defects. It also reduces the rate of proliferation of callus cells in healing bone fractures. In this study se was shown not to affect rate of regeneration of liver, thymus, or connective tissue.
Short-eared mice have many anatomical abnormalities of the soft tissues including medial displacement of the left gonad, ventral displacement of the right renal artery, hydroureter and hydronephrosis, giant cell granulomas on the ventral surface of the liver, and on some genetic backgrounds an increased frequency of cysts of the lungs. Young se/se mice often have neuromuscular waviness of the tail. In the heterozygous condition (+/se) the gene causes a slight reduction in skeletal size and a slight increase in frequency of hydroureter, liver lesions, lung cysts, and wavy tail. It was shown that the viscera appear to be crowded from the 11-day stage of gestation and that crowding is probably responsible for the abnormalities of the left gonad, the right renal artery, and the ureter, and is possibly a contributing cause of the granulomas of the liver. The probable cause of the crowding is the slower growth of the skeleton, resulting in a body cavity too small to accommodate the visceral mass of normal size. It is not clear that crowding is a sufficient explanation of the liver lesions or that it explains the effect of se on frequency of lung cysts or on waviness of the tail.