RISK-FACTORS FOR STROKE IN MIDDLE-AGED MEN IN GOTEBORG, SWEDEN
RISK-FACTORS FOR STROKE IN MIDDLE-AGED MEN IN GOTEBORG, SWEDEN
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DOI：
10.1161/01.str.21.2.223
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发表时间：
1990-02-01
期刊：
影响因子：
8.3
通讯作者：
WILHELMSEN, L
中科院分区：
文献类型：
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作者：
HARMSEN, P;ROSENGREN, A;WILHELMSEN, L
为了评价瑞典哥德堡的卒中危险因素，在1970-1973年期间，对来自9，998名年龄在47-55岁的男性的一般人群样本的7，495名参与男性的队列进行了心血管危险因素检查。男性高血压和高胆固醇血症和男性谁是重度吸烟者进行了治疗。我们使用卒中登记和死亡证明评估卒中终点和病因特异性死亡率。在平均11.8年的随访中，整个人群样本（参与者和非参与者）中发生了230例卒中（7%蛛网膜下腔出血，13%脑内出血，42%脑梗死和38%未指明的卒中）。使用单变量分析，我们发现测量的高血压（收缩压和舒张压），吸烟，已知的高血压，糖尿病，父母任何一方中风，严重的心理压力，婚姻状况，房颤，既往短暂性脑缺血发作，既往心肌梗死，努力引起的胸痛和间歇性跛行与所有中风显著相关。在中风类型中，蛛网膜下腔出血与这些指标中的任何一个都不相关，而脑出血仅与测量的高血压相关。使用多变量分析，我们发现测量的高血压，吸烟，严重的心理压力以及房颤，既往短暂性脑缺血发作和间歇性跛行是非出血性卒中的独立危险因素。血清胆固醇浓度、职业和业余体力活动、体重指数、酗酒和低职业等级不是脑卒中的危险因素。
To evaluate stroke risk factors in Goteborg, Sweden, during 1970-1973 a cohort of 7,495 participating men from a general population sample of 9,998 men aged 47-55 years were examined with respect to cardiovascular risk factors. Men with hypertension and hypercholesterolemia and men who were heavy smokers were treated. We assessed stroke end points and cause-specific mortality using a stroke register and death certificates. During a mean follow-up of 11.8 years, 230 strokes occurred in the entire population sample (participants and nonparticipants) (7% subarachnoid hemorrhages, 13% intracerebral hemorrhages, 42% cerebral infarctions, and 38% unspecified strokes). Using univariate analysis, we found measured high blood pressure (systolic and diastolic), smoking, known hypertension, diabetes mellitus, stroke in either parent, severe psychological stress, marital status, atrial fibrillation, previous transient ischemic attacks, previous myocardial infarction, effort-induced chest pain, and intermittent claudication to be significantly related to all stroke. Of the stroke types, subarachnoid hemorrhage was not related to any of these indicators, and intracerebral hemorrhage was related only to measured high blood pressure. Using multivariate analyses, we found measured high blood pressure, smoking, and severe psychological stress as well as atrial fibrillation, previous transient ischemic attacks, and intermittent claudication to be independent risk factors for nonhemorrhagic stroke. Serum cholesterol concentration, occupational and leisure-time physical activity, both mass index, alcohol abuse, and low occupational class were not risk factors for stroke.