Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype
Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype
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DOI：
10.1021/np970065o
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发表时间：
1998-01-01
影响因子：
5.1
通讯作者：
Krawiec, M
中科院分区：
文献类型：
--
作者：
Ma, GX;Wang, TS;Krawiec, M
从新疆产的短叶蜉蝣（Ephemerantha lonchophylla）的茎中分得两个新的海松烷型二萜化合物：长叶蜉蝣素A（1）和B（2）。1和2的结构主要通过广泛的H-1-和C-13-NMR，1D-和2D-同相和异相相关NMR实验，和X-射线衍射方法的应用来确定。与结构-活性预测一致，这两种化合物都能够使表达多药耐药表型的细胞对抗癌药物阿霉素的毒性敏感。
Two new pimarane diterpenoids, lonchophylloids A(1) and B (2), were isolated from the stems of Ephemerantha lonchophylla. The structures of 1 and 2 were established predominantly through the application of extensive H-1-and C-13-NMR, 1D-and 2D-homonuclear and heteronuclear correlation NMR experiments, and X-ray diffraction methods. Consistent with structure-activity predictions, both compounds were capable of sensitizing cells that expressed the multidrug resistance phenotype to the toxicity of the anticancer drug doxorubicin.