IRREGULAR BREATHING AND HYPOXAEMIA DURING SLEEP IN CHRONIC STABLE ASTHMA
IRREGULAR BREATHING AND HYPOXAEMIA DURING SLEEP IN CHRONIC STABLE ASTHMA
复制标题
慢性稳定性哮喘睡眠期间呼吸不规则和低氧血症
DOI：
10.1016/s0140-6736(82)91567-7
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
D. Flenley
中科院分区：
文献类型：
--
作者：
J. Catterall;P. Calverley;V. Březinová;N. Douglas;H. Brash;C. Shapiro;D. Flenley
在10名成人稳定型哮喘患者和10名年龄匹配的健康受试者中比较了呼吸模式、耳血氧饱和度（SaO 2）和EEG睡眠阶段。两组人的睡眠时间相同（5.0 ~ 7.2小时，平均6.2小时），但哮喘患者的睡眠不太好;他们比健康受试者有更多的觉醒、困倦和呼吸不规则的时间。他们的血氧饱和度也有更大和更频繁的福尔斯下降。大多数低氧血症发作发生在睡眠的快速眼动期，并与呼吸不足或呼吸暂停有关，但没有患者有典型的睡眠呼吸暂停综合征。夜间低氧血症的严重程度与受试者清醒时的SaO 2水平有关，但与睡眠后10名哮喘患者中有8名记录的用力呼气量下降无关。
Breathing patterns, ear oxygen saturation (SaO2), and EEG sleep-stage throughout an undisturbed night's sleep were compared in ten adult stable asthmatics and ten age-matched healthy subjects. The two groups slept equally long (5·0-7·2, mean 6·2 h), but the asthmatics slept less well; they had more periods of wakefulness and drowsiness and irregular breathing than did the healthy subjects. They also had greater and more frequent falls in SaO2. Most hypoxaemic episodes occurred in the rapid-eye-movement phase of sleep and were associated with hypopnoea or apnoea, but no patient had a classical sleep-apnoea syndrome. The severity of nocturnal hypoxaemia was related to the level of SaO2when the subjects were awake, but did not correlate with the fall in forced expiratory volume recorded in eight out of ten asthmatics after sleep.