Hippocampal head size associated with verbal memory performance in nondemented elderly
Hippocampal head size associated with verbal memory performance in nondemented elderly
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DOI：
10.1006/nimg.2002.1248
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发表时间：
2002-11-01
期刊：
影响因子：
5.7
通讯作者：
Breteler, MMB
中科院分区：
文献类型：
--
作者：
Hackert, VH;den Heijer, T;Breteler, MMB
海马体在记忆的巩固中起着至关重要的作用。在解剖学上，海马体的头部、体部和尾部连接到内嗅皮层的不同区域，内嗅皮层将处理后的信息从联合皮层传递到海马体。然而，人们对它的纵轴沿着的功能隔离知之甚少。在本研究中，我们调查是否海马头部，身体，或尾巴是选择性地参与言语记忆的表现。共有511名年龄在60-90岁之间的非痴呆参与者在1.5 T MRI单元中进行了三维HASTE脑部扫描。通过在冠状切片上手动描记来测量海马体积。根据预定义的截止值，在前后方向上进行分割，分别将35%、45%和20%的切片分配给头部、身体和尾部。记忆表现通过15个单词的学习测试进行评估，包括即时和延迟回忆的任务。为了分析头部、身体和尾部体积与记忆性能之间的关联，我们使用多元线性回归，调整年龄、性别、教育和中矢状面积作为颅内体积的代表。海马头部较大的受试者在记忆测试中得分显著较高，最显著的是延迟回忆（左海马头部每SD增加0.41个词（95%CI（0.16，0.67）），右海马头部每SD增加0.33个词（95%CI 0.06，0.59））。我们的数据表明，选择性参与的海马头部在言语记忆，并添加到最近的发现功能隔离沿着纵向轴的海马。(C)2002 Elsevier Science（美国）。
The hippocampus plays a crucial role in the consolidation of memory. Anatomically, the hippocampal head, body, and tail are connected to separate regions of the entorhinal cortex, which conveys processed information from the association cortices to the hippocampus. Little is known, however, about the functional segregation along its longitudinal axis. In the present study, we investigated whether the hippocampal head, body, or tail is selectively involved in verbal memory performance. A total of 511 nondemented participants, aged 60-90 years, underwent a three-dimensional HASTE brain scan in a 1.5-T MRI unit. Hippocampal volumes were measured by manual tracing on coronal slices. Segmentation was performed in anterior-posterior direction on the basis of predefined cutoffs allocating 35, 45, and 20% of slices to the head, body, and tail, respectively. Memory performance was assessed by a 15-word learning test including tasks of immediate and delayed recall. To analyze the association between head, body, and tail volumes and memory performance, we used multiple linear regression, adjusting for age, sex, education, and midsagittal area as a proxy for intracranial volume. Participants with larger hippocampal heads scored significantly higher in the memory test, most notably in delayed recall (0.41 word per SD increase in left hippocampal head (95% Cl (0.16,0.67)),0.33 word per SD increase in right hippocampal head (95% Cl 0.06, 0.59)). Our data suggest selective involvement of the hippocampal head in verbal memory, and add to recent findings of functional segregation along the longitudinal axis of the hippocampus. (C) 2002 Elsevier Science (USA).