Antipsychotics and Medical Comorbidity: A Retrospective Study in an Urban Outpatient Psychiatry Clinic.
Antipsychotics and Medical Comorbidity: A Retrospective Study in an Urban Outpatient Psychiatry Clinic.
复制标题
抗精神病药物和医疗合并症：城市精神病门诊的回顾性研究。
DOI：
10.1007/s10597-022-01045-2
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发表时间：
2023
影响因子：
2.7
通讯作者：
Goldsmith,DavidR
中科院分区：
文献类型：
--
作者：
Bennett,CatherineW;Gensler,Lauren;Goldsmith,DavidR
精神病患者的医疗合并症发生率增加。在这项横断面研究中，我们调查了在佐治亚州亚特兰大市的一家城市精神病学诊所（n = 860）的精神障碍患者中抗精神病药物与医疗合并症之间的关系。将每个抗精神病药物组与同一样本中未使用任何抗精神病药物的一组患者进行比较，并为每种合并症构建逻辑回归模型。齐拉西酮与糖尿病（aOR 2.56, 95% CI 1.03-6.38）和肥胖（aOR 3.19, 95% CI 1.37-7.41）相关。阿立哌唑与肥胖相关（aOR 2.39, 95% CI 1.27-4.51）。氯氮平与胃食管反流（aOR 3.59, 95% CI 1.11-11.61）、运动障碍（aOR 4.44, 95% CI 1.02-19.32）和心律失常（4.89,95% CI 1.44-16.64）相关。两种被认为是体重中性的抗精神病药物齐拉西酮和阿立哌唑与心脏代谢合并症有关。这项研究表明，研究抗精神病药物、医疗共病和精神病症状负担之间的关系是有必要的。
Patients with psychotic disorders have increased rates of medical comorbidities. In this cross-sectional study, we investigated the relationship between antipsychotics and medical comorbidities among patients with psychotic disorders in an urban psychiatry clinic in Atlanta, Georgia (n = 860). Each antipsychotic group was compared to a group of patients from the same sample who were not on any antipsychotic, and logistic regression models were constructed for each comorbidity. Ziprasidone was associated with diabetes (aOR 2.56, 95% CI 1.03–6.38) and obesity (aOR 3.19, 95% CI 1.37–7.41). Aripiprazole was associated with obesity (aOR 2.39, 95% CI 1.27–4.51). Clozapine was associated with GERD (aOR 3.59, 95% CI 1.11–11.61), movement disorders (aOR 4.44, 95% CI 1.02–19.32), and arrythmias (4.89, 95% CI 1.44–16.64). Two antipsychotics that are considered weight neutral, ziprasidone and aripiprazole, were associated with cardiometabolic comorbidities. This study suggests that research is warranted to study the association between antipsychotics, medical comorbidity, and psychotic symptom burden.