Distribution of urinary selenium and arsenic among pregnant women exposed to arsenic in drinking water
Distribution of urinary selenium and arsenic among pregnant women exposed to arsenic in drinking water
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DOI：
10.1016/j.envres.2005.03.009
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发表时间：
2006-01-01
影响因子：
8.3
通讯作者：
Todorov, T
中科院分区：
文献类型：
--
作者：
Christian, WJ;Hopenhayn, C;Todorov, T
无机砷（In-As）是一种常见的有毒和致癌物质，广泛存在于世界各地的地表水和地下水中。暴露可导致皮肤损伤、不良生殖结果和癌症。砷（As）在人体内的代谢主要有两条途径：还原反应和氧化甲基化反应。氧化甲基化反应是指甲基与As化合物结合形成甲基胂酸盐（MMA）和二甲基胂酸盐（DMA）。MMA、DMA和In-As经尿液排泄。另一种类金属，硒（Se），尿水平最近已被证明是与增加作为排泄和改变代谢产物分布。本研究调查了这种关联，在智利砷和生殖影响的一个更大的前瞻性研究中收集的数据。这项分析包括来自安托法加斯塔的93名孕妇。人口统计学，行为和其他特征的数据，通过训练有素的助产士进行的访谈，并现场尿样进行了分析，砷和硒浓度使用电感耦合等离子体质谱法（ICP-MS）。尿硒与尿砷呈显著正相关（r = 0.68，P < 0.01）。多元线性回归分析显示，尿硒水平升高与尿砷排泄量增加、%DMA、.降低了%In-As。本研究的结果表明，在接触砷的人群中，硒摄入量可能与尿砷排泄量相关，并可能改变砷甲基化。(c)2005年爱思唯尔公司All rights reserved.
Inorganic arsenic (In-As) is a well-known toxicant and carcinogen found naturally in surface and groundwater around the world. Exposure can cause skin lesions, adverse reproductive outcomes, and cancer. There are two main pathways of arsenic (As) metabolism in humans: the reduction reactions, and the oxidative methylation reactions, where methyl groups are attached to As compounds to form monomethylarsenate (MMA) and dimethylarsenate (DMA). MMA, DMA, and In-As are excreted in urine. Urinary levels of another metalloid, selenium (Se), have recently been shown to be associated with increased As excretion and altered metabolite distribution. This study investigates this association, using data collected in a larger prospective study of arsenic and reproductive effects in Chile. This analysis included 93 pregnant women from Antofagasta. Data on demographic, behavioral, and other characteristics were obtained via interviews conducted by trained midwives, and spot urine samples were analyzed for As and Se concentration using inductively coupled plasma-mass spectrometry (ICP-MS). Urinary Se levels were found to be correlated with urinary As levels in bivariate analysis (r = 0.68, P < 0.01). Multiple linear regression analyses revealed that higher urinary Se levels were associated with increased urinary As excretion, increased %DMA,. and decreased %In-As. The results of this study suggest that in populations exposed to arsenic, Se intake may be correlated with urinary As excretion, and may alter As methylation. (c) 2005 Elsevier Inc. All rights reserved.