Dual Oxidation State Tandem Catalysis in the Palladium-Catalyzed Isomerization of Alkynyl Epoxides to Furans
Dual Oxidation State Tandem Catalysis in the Palladium-Catalyzed Isomerization of Alkynyl Epoxides to Furans
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DOI：
10.1021/acscatal.8b02248
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发表时间：
2018-09-01
期刊：
影响因子：
12.9
通讯作者：
Anderson, Edward A.
中科院分区：
文献类型：
--
作者：
Arroniz, Carlos;Chaubet, Guilhem;Anderson, Edward A.
介绍了一种由不同氧化态钯组成的双催化剂体系，该体系催化烷基环氧化物异构化生成呋喃。在称为“双氧化态串联催化”的过程中，描述了一个多步异构化途径，其中不同的金属氧化态和配体发挥独立的机制作用，但它们结合在一起，可以使用比单独使用单一催化剂更温和的反应条件和更低的催化剂负载。在目前的情况下，这种罕见的同双金属催化转化的例子为呋喃合成提供了一种温和的、可扩展的和原子高效的途径。
A two-catalyst system consisting of different oxidation states of palladium is described, which mediates the isomerization of alkynyl epoxides to furans. In a process termed "dual oxidation state tandem catalysis", a multistep isomerization pathway is delineated in which the different metal oxidation states and ligands play independent mechanistic roles, but which, in combination, enable the use of milder reaction conditions and lower catalyst loadings than a single catalyst in isolation. In the present context, this rare example of a homobimetallic catalytic transformation provides a mild, scalable, and atom-efficient route for furan synthesis.