Affective temperaments play an important role in the relationship between child abuse and the diagnosis of bipolar disorder
Affective temperaments play an important role in the relationship between child abuse and the diagnosis of bipolar disorder
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情感气质在儿童虐待与躁郁症诊断之间的关系中发挥着重要作用
DOI：
10.1016/j.psychres.2018.01.040
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发表时间：
2018
影响因子：
11.3
通讯作者：
Kusumi Ichiro
中科院分区：
文献类型：
--
作者：
Toda Hiroyuki;Inoue Takeshi;Tanichi Masaaki;Saito Taku;Nakagawa Shin;Masuya Jiro;Tanabe Hajime;Yoshino Aihide;Kusumi Ichiro
在以前的研究中，各种因素，如环境和遗传因素已被证明有助于双相情感障碍（BD）的发展。本研究调查了多种因素，包括虐待儿童，成人生活事件和情感气质，是如何相互关联的，以及它们如何影响BD的诊断。共有170名健康对照者和75名BD患者完成了以下自填问卷：患者健康问卷-9评估抑郁症状的严重程度;儿童虐待和创伤量表（CATS）评估儿童虐待;孟菲斯、比萨、巴黎和圣地亚哥自我气质评估问卷（TEMPS-A）评估情感气质;生活经历调查（LES）评估消极和积极的成人生活事件。数据进行单变量分析，多变量分析和结构方程模型。结构方程模型表明，BD的诊断是间接预测的忽视和性虐待得分的CATS通过四个情感气质（抑郁，循环情感，易怒，焦虑）的TEMPS-A和直接预测这四个情感气质。本研究提示，情感气质在儿童虐待对BD诊断的影响中起着重要的中介作用。
In previous studies, various components such as environmental and genetic factors have been shown to contribute to the development of bipolar disorder (BD). This study investigated how multiple factors, including child abuse, adult life events, and affective temperaments, are interrelated and how they affect the diagnosis of BD. A total of 170 healthy controls and 75 BD patients completed the following self-administered questionnaires: the Patient Health Questionnaire-9 evaluating the severity of depressive symptoms; the Child Abuse and Trauma Scale (CATS) evaluating child abuse; the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS-A) evaluating affective temperaments; and the Life Experiences Survey (LES) evaluating negative and positive adult life events. The data were subjected to univariate analysis, multivariable analysis, and structural equation modeling. The structural equation modeling showed that the diagnosis of BD was indirectly predicted by the neglect and sexual abuse scores of the CATS through four affective temperaments (depressive, cyclothymic, irritable, and anxious) of the TEMPS-A and directly predicted by these four affective temperaments. This study suggested that affective temperament plays an important role as a mediator in the influence of child abuse on BD diagnosis.