Photoperiod-induced differences in uterine growth in Phodopus sungorus are evident at an early age when serum estradiol and uterine estrogen receptor levels are not different
Photoperiod-induced differences in uterine growth in Phodopus sungorus are evident at an early age when serum estradiol and uterine estrogen receptor levels are not different
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DOI：
10.1016/j.cbpa.2009.10.024
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发表时间：
2010-01-01
影响因子：
2.3
通讯作者：
Place, Ned J.
中科院分区：
文献类型：
--
作者：
Phalen, Adrien N.;Wexler, Ron;Place, Ned J.
西伯利亚仓鼠（Photopus sungorus）的性发育在短日照（SD）内受到抑制，小子宫是光抑制的一个明显指标。SD大鼠子宫小可能是由于发情周期开始延迟所致。然而，在早期的研究中，研究人员报告说，血清雌二醇（E2）浓度显着较高的年轻女性提出了在SD比长日（LD），与最高浓度测量SD在4周龄。本研究对这些看似矛盾的发现进行了调查。首先，测量SD和LD饲养的仓鼠从1至12周龄的子宫质量和体重。在3周龄及以后，LD组的子宫质量显著大于SD组。此后，我们的研究集中在4周龄的仓鼠。血清E2浓度在LD和SD没有显着差异，有没有显着的LD-SD差异子宫雌激素受体（ER），通过免疫组化和定量实时RT-PCR测定。因此，被认为是在年轻的西伯利亚仓鼠子宫大小的光周期差异的替代解释。(C)2009 Elsevier Inc. All rights reserved.
Sexual development is inhibited in Siberian hamsters (Phodopus sungorus) in short days (SD), and a small uterus is an obvious indicator of photo-inhibition. The small uterus in SD is presumably due to the delayed onset of estrous cycles. However, in an earlier study, the investigators reported that serum estradiol (E2) concentration was significantly higher in young females raised in SD than in long days (LD), with the highest concentrations measured in SD at 4 weeks of age. These seemingly contradictory findings were investigated in the present study. First, uterine mass and body mass were measured in SD- and LD-reared hamsters from I to 12 weeks of age. Uterine mass was significantly greater in LD than in SD by 3 weeks of age and onward. Thereafter, our investigation focused on 4-week-old hamsters. Serum E2 concentrations in LD and in SD were not significantly different and there were no significant LD-SD differences in uterine estrogen receptors (ER), as measured by immunohistochemistry and quantitative real-time RT-PCR. Therefore, alternative explanations for the photoperiodic difference in uterine size in young Siberian hamsters are considered. (C) 2009 Elsevier Inc. All rights reserved.