Association of serum MIP-1α, MIP-1β, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus
Association of serum MIP-1α, MIP-1β, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus
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DOI：
10.1007/s10067-006-0387-y
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发表时间：
2007-05-01
影响因子：
3.4
通讯作者：
Rios, Zilka
中科院分区：
文献类型：
--
作者：
Vila, Luis M.;Molina, Maria J.;Rios, Zilka
本研究的目的是确定巨噬细胞炎性蛋白（MIP）1 α、MIP-1 β和RANTES（在正常T细胞表达和分泌的活化后调节）血清浓度是否与系统性红斑狼疮（SLE）患者的临床表现、疾病活动和损伤累积相关。在参与纵向研究的62名SLE患者（根据美国流变学学会标准）和20名健康受试者中进行了横断面研究。采用酶联免疫吸附试验测定MIP-1 α、MIP-1 β和RANTES血清浓度。在研究访视时确定人口统计学参数、临床表现、血清学特征、药物治疗、疾病活动和损伤累积。用系统性红斑狼疮活动性测量（SLAM）评估疾病活动性，用系统性红斑狼疮国际合作临床损伤指数（SDI）评估疾病损伤。采用Student t检验和Pearson r相关性检验研究变量之间的关系。SLE患者的MIP-1 β和RANTES浓度高于健康人。此外，他们有一个趋势，有较高浓度的MIP-1 α。盘状狼疮患者更可能有较高水平的MIP-1 α。MIP-1 β升高与SDI评分升高相关。血清趋化因子水平与疾病活动性之间无相关性。总之，SLE患者血清MIP-1 β和RANTES水平高于健康人。MIP-1 α与盘状狼疮相关，MIP-1 β与SLE损伤累积相关。本研究提示趋化因子可能在SLE的发病机制中起一定作用。
The aim of this study was to determine if macrophage inflammatory protein (MIP) 1 alpha, MIP-1 beta, and RANTES (regulated upon activation normally T-cell expressed and secreted) serum concentrations are associated with clinical manifestations, disease activity, and damage accrual in patients with systemic lupus erythematosus (SLE). A cross-sectional study was performed in 62 SLE patients (per American College of Rheumatology criteria) participating in a longitudinal study and 20 healthy subjects. MIP-1 alpha, MIP-1 beta, and RANTES serum concentrations were determined by enzyme-linked immunosorbent assay. Demographic parameters, clinical manifestations, serologic features, pharmacologic treatments, disease activity, and damage accrual were determined at study visit. Disease activity was assessed with the Systemic Lupus Erythematosus Activity Measure (SLAM), and disease damage was assessed with Systemic Lupus International Collaborating Clinic Damage Index (SDI). The relation between the variables was studied with the Student t test and the Pearson r correlation test. SLE patients were more likely to have higher concentrations of MIP-1 beta and RANTES than healthy individuals. In addition, they had a trend to have higher concentrations of MIP-1 alpha. Patients with discoid lupus were more likely to have higher levels of MIP-1 alpha. Elevation of MIP-1 beta correlated with higher SDI score. No association was found between serum chemokines levels and disease activity. In conclusion, SLE patients have higher serum levels of MIP-1 beta and RANTES than healthy individuals. MIP-1 alpha is associated with discoid lupus, and MIP-1 beta correlates with damage accrual in SLE. This study suggests that chemokines may have a role in the pathogenesis of SLE.