Periconceptional maternal fever, folic acid intake, and the risk for neural tube defects.
Periconceptional maternal fever, folic acid intake, and the risk for neural tube defects.
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DOI：
10.1016/j.annepidem.2017.10.010
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发表时间：
2017-12
影响因子：
5.6
通讯作者：
Werler MM
中科院分区：
文献类型：
--
作者：
Kerr SM;Parker SE;Mitchell AA;Tinker SC;Werler MM
先前的研究表明，母亲在怀孕早期发热和神经管缺陷（NTDs），如脊柱裂之间的关联。围产期叶酸摄入已被证明可以降低这些结果的风险。使用斯隆流行病学中心出生缺陷研究（1998-2015）的数据，我们研究了叶酸对围受孕期（末次月经前后28天）母体发热与NTD之间关系的影响。Logistic回归模型用于计算调整的比值比（OR）和95%置信区间（CI）。包括375例病例和8247例正常对照的母亲。我们观察到在围受孕期发热的NTD风险升高（OR：2.4; 95%CI：1.5-4.0）。与叶酸摄入量低的母亲（<400 μg/天; OR：4.2; 95% CI：2.2-8.2）相比，报告摄入推荐量叶酸的母亲（≥ 400 μg/天; OR：1.8; 95% CI：0.8-4.0）的这种关联较弱。我们的数据支持产妇围产期发热和NTD风险增加之间的关联，也提供了证据表明，这种关联是减弱的母亲谁报告消费叶酸在推荐的水平在围产期。
Previous studies have shown an association between maternal fever in early pregnancy and neural tube defects (NTDs) such as spina bifida. Periconceptional folic acid intake has been shown to reduce the risk of these outcomes. Using data from the Slone Epidemiology Center Birth Defects Study (1998–2015), we examined the impact of folic acid on the relationship between maternal fever in the periconceptional period (28 days before and after the last menstrual period) and NTDs. Logistic regression models were used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Mothers of 375 cases and 8247 nonmalformed controls were included. We observed an elevated risk for NTDs for fever in the periconceptional period (OR: 2.4; 95% CI: 1.5–4.0). This association was weaker for mothers who reported consuming the recommended amount of folic acid (≥ 400 μg per day; OR: 1.8; 95% CI: 0.8–4.0) than mothers with low folic acid intake (<400 μg per day; OR: 4.2; 95% CI: 2.2–8.2). Our data support an association between maternal periconceptional fever and an increased risk for NTDs and also provide evidence that this association was attenuated for mothers who reported consuming folic acid at recommended levels in the periconceptional period.
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影响因子：
5
作者：
WILLETT, W;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
DOI：
10.1016/s0165-3806(01)00295-4
发表时间：
2001-12-14
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Hinoue, A;Fushiki, S;Shiota, K
通讯作者：
Shiota, K
影响因子：
5.5
作者：
Tinker, Sarah C.;Cogswell, Mary E.;Berry, Robert J.
通讯作者：
Berry, Robert J.
影响因子：
4.2
作者：
Shin, JH;Shiota, K
通讯作者：
Shiota, K
影响因子：
5.4
作者：
Botto, LD;Erickson, JD;Liu, YC
通讯作者：
Liu, YC