The Adult Life After Childhood Cancer in Scandinavia (ALiCCS) Study: Design and Characteristics
The Adult Life After Childhood Cancer in Scandinavia (ALiCCS) Study: Design and Characteristics
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DOI：
10.1002/pbc.25661
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发表时间：
2015-12-01
影响因子：
3.2
通讯作者：
Olsen, Jorgen H.
中科院分区：
文献类型：
--
作者：
Asdahl, Peter H.;Winther, Jeanette F.;Olsen, Jorgen H.
背景在过去的50年中，儿童癌症的存活率从25%增加到80%。然而，与此同时，很明显，幸存者经历了广泛的与治疗有关的晚期不良健康影响。斯堪的纳维亚儿童癌症后的成人生活（ALiCCS）研究的目的是调查过去和当前治疗的长期健康后果，以改善幸存者的随访护理，并降低未来患者的治疗相关发病率。Procedure.通过五个北欧癌症登记处确定了儿童癌症幸存者，并通过从民事登记系统中随机选择无癌症个体建立了一个比较队列。使用唯一的个人识别号码将不同的健康登记处联系起来。提取一部分幸存者的治疗信息，可以调查癌症治疗的各个组成部分与晚期发生的合并症之间的关系。结果儿童癌症幸存者队列包括33，160名1年幸存者，对照队列包括212，892名来自普通人群的无癌症个体。在儿童癌症幸存者队列中，所有类型的儿童癌症都有代表性，包括白血病（21%），淋巴瘤（14%），中枢神经系统肿瘤（24%），肉瘤（5%），视网膜母细胞瘤（3%）和神经母细胞瘤（4%）。在幸存者中，22%的人在40岁以上接受了随访。结论ALiCCS研究构成了一个新的大型资源，用于研究儿童癌症的晚期影响，包括所有类型的儿童恶性肿瘤，并跟踪了大部分幸存者到成年后期。(C)2015年威利期刊公司
Background. During the last five decades, survival of childhood cancer has increased from 25% to 80%. At the same time, however, it has become evident that survivors experience a broad range of therapy-related late adverse health effects. The aim of the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study is to investigate long-term health consequences of past and current therapies in order to improve follow-up care of survivors and to reduce treatment-related morbidity of future patients. Procedure. Childhood cancer survivors were identified through the five Nordic cancer registries and a comparison cohort was established through random selection of cancer-free individuals from the civil registration systems. A unique personal identification number was used to link between different health registries. Abstraction of treatment information for a subset of survivors allows investigation of the association between the various components of cancer therapy and late occurring comorbidity. Results. The childhood cancer survivor cohort comprises 33,160 1-year survivors and the comparison cohort comprises 212,892 cancer free individuals from the general population. In the childhood cancer survivor cohort, all types of childhood cancer are represented including leukemia (21%), lymphoma (14%), central nervous system tumors (24%), sarcomas (5%), retinoblastoma (3%), and neuroblastoma (4%). Among the survivors, 22% have been followed beyond the age of 40 years. Conclusion. The ALiCCS study constitutes a new large resource for research on late effects of childhood cancers that include all types of childhood malignancies and has followed a large proportion of the survivors well into late adulthood. (C) 2015 Wiley Periodicals, Inc.