Sex differences in plasma prolactin response to tryptophan in chronic fatigue syndrome patients with and without comorbid fibromyalgia.
Sex differences in plasma prolactin response to tryptophan in chronic fatigue syndrome patients with and without comorbid fibromyalgia.
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患有或不患有纤维肌痛的慢性疲劳综合征患者血浆催乳素对色氨酸反应的性别差异。
DOI：
10.1089/jwh.2009.1697
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Natelson,BenjaminH
中科院分区：
文献类型：
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作者：
Weaver,ShelleyA;Janal,MalvinN;Aktan,Nadine;Ottenweller,JohnE;Natelson,BenjaminH
背景：一些人认为慢性疲劳综合征(CFS)和纤维肌痛(FM)是同一疾病过程的变体。这意味着患有和不伴有FM的CFS患者有相似的生物学基础。为了验证这一点，我们比较了单纯慢性疲劳综合征患者、慢性疲劳综合征 + FM患者和健康对照组基于5-羟色胺能的反应、血浆催乳素(PRL)和自我报告的疲劳度。方法：单独患有慢性疲劳综合征或CFS + FM的男性和女性以及健康受试者，没有目前的严重抑郁障碍，每公斤瘦体重静脉注射120 mg的l-色氨酸。结果：与对照组相比，单纯慢性疲劳综合征患者血浆催乳素、色氨酸和犬尿氨酸水平明显升高，而非慢性疲劳综合征患者 + FM患者的血浆催乳素水平明显升高。在不同的男性群体中没有差异。血浆色氨酸和犬尿氨酸浓度在不同组之间没有差异。结论：这些结果表明，仅患有CFS的女性有升高的5-羟色胺能张力，这在合并FM的女性中是看不到的。在男性中缺乏影响表明了一种机制，可能在一定程度上解释了女性CFS患病率的增加。这些数据支持这样的解释，即女性的CFS是一种不同于FM的疾病。
Background:Some think chronic fatigue syndrome (CFS) and fibromyalgia (FM) are variants of the same illness process. This would imply that CFS patients with and without comorbid FM have similar biological underpinnings. To test this, we compared serotonergic-based responses, plasma prolactin (PRL), and self-reported measures of fatigue to intravenous infusion of tryptophan among patients with CFS alone, CFS + FM, and healthy controls.Methods:Men and women with CFS alone or CFS + FM and healthy subjects, none with current major depressive disorder (MDD), were given 120 mg ofl-tryptophan per kg lean body mass intravenously (i.v.). Before and after tryptophan infusion, blood samples were collected, and plasma PRL, tryptophan, and kynurenine concentrations were determined.Results:Women with CFS alone, but not CFS + FM, showed upregulated plasma PRL responses compared with controls. There were no differences among groups of men. Plasma tryptophan and kynurenine concentrations did not differ among groups.Conclusions:These results indicate that women with CFS alone have upregulated serotonergic tone that is not seen in those with comorbid FM. The lack of effect in men suggests a mechanism that might explain, in part, the increased prevalence of CFS in women. The data support the interpretation that CFS in women is a different illness from FM.