Coronary risk in South Asians: role of ethnicity and blood sugar
Coronary risk in South Asians: role of ethnicity and blood sugar
复制标题
DOI：
10.1097/00149831-200410000-00005
复制
发表时间：
2004-10-01
影响因子：
--
通讯作者：
Jackson, PR
中科院分区：
文献类型：
--
作者：
Aarabi, M;Jackson, PR
背景研究南亚移民在不同的国家报道了增加易感性心血管疾病相比，与本地population.Design这项研究是一个系统的回顾纵向研究调查的差异，在建立的危险因素之间的冠心病（CHD）高加索人和南亚人。其目的是开发一种实用的工具来估计个人CHD风险。其次，从英国健康调查1999年（HSE 1999年）的数据被用来探讨可能的作用，血糖的差异，在风险variation.Methods我们使用了系统的搜索，找到相关的发表论文。采用HSE 1999的数据研究血糖和糖基化血红蛋白的种族差异。结果5项纵向研究中只有2项报告了南亚人与高加索人相比冠心病相对危险度的独立估计。经典危险因素可充分预测南亚糖尿病患者的风险，而非糖尿病研究人群的风险比预测值高79%。非糖尿病南亚人有较高的空腹血糖（FBG）和HbA（1C）比高加索人调整后的CHD危险factors.Conclusions之间的差异，非糖尿病南亚人和高加索人冠心病的风险是不能解释的传统危险因素的影响的差异。部分原因可能是非糖尿病南亚人的血糖浓度较高。(C)2004年欧洲心脏病学会
Background Studies of South Asian immigrants in different countries have reported an increased predisposition to cardiovascular disease in comparison with the native populations.Design This study is a systematic review of longitudinal studies investigating differences in established risk factors for coronary heart disease (CHD) between Caucasians and South Asians. The aim was to develop a practical tool to estimate CHD risk in individuals. Secondarily data from the Health Survey for England 1999 (HSE 1999) were used to explore a possible role of differences in blood glucose in risk variation.Methods We used a systematic search to find relevant published papers. Data from the HSE 1999 were employed to study ethnic differences in blood glucose and glycosylated haemoglobin. Results Only two out of five longitudinal studies reported independent estimates of relative risks of CHD in South Asians compared to Caucasians. Risk in diabetic South Asians was predicted adequately by classical risk factors whilst risk in a non-diabetic study population was 79% greater than predicted. Non-diabetic South Asians have higher fasting blood glucose (FBG) and HbA(1c) than Caucasians after adjustment for CHD risk factors.Conclusions The difference in risk of CHD between non-diabetic South Asian and Caucasians is not explained by differences in the impact of the traditional risk factors. Part may be due to higher blood sugar concentrations in nondiabetic South Asians. (C) 2004 The European Society of Cardiology