Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
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尼卡斯特林是组装早老素/γ-分泌酶复合物以介导Notch信号传导以及哺乳动物中β-淀粉样前体蛋白的加工和运输所必需的。
DOI:
10.1523/jneurosci.23-08-03272.2003
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发表时间:
2003
期刊:
影响因子:
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通讯作者:
Wong,PhilipC
中科院分区:
文献类型:
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作者:
Li,Tong;Ma,Guojun;Cai,Huaibin;Price,DonaldL;Wong,PhilipC