Pathogenesis sequences in Gejiu miners with lung cancer: an introduction
Pathogenesis sequences in Gejiu miners with lung cancer: an introduction
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DOI：
10.1007/s11684-015-0399-6
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发表时间：
2015-09-01
影响因子：
8.1
通讯作者：
Jin, Kewei
中科院分区：
文献类型：
--
作者：
Bian, Li;Ruan, Yonghua;Jin, Kewei
中国云南省个旧市锡矿工人是肺癌的高危人群，具有显著的职业特征。这些矿工的组织样本呈现出病理特征，如癌中的纤维增生、肺癌中的癌周组织以及癌周组织中上皮细胞的增生和异型增生。云锡矿尘诱发的肿瘤在动物实验中经历了上皮细胞的炎症、纤维增生、增生、异型增生和癌变过程。矿尘体外诱导的支气管上皮细胞转化与成纤维细胞活化之间存在相关和协同关系。成纤维细胞的增生和活化是促进上皮细胞转化和癌变的重要因素。我们的研究结果表明，肺纤维化可能会增加风险，促进肺癌的发生，这可能会导致肺纤维增生。
Tin miners in Gejiu, Yunnan Province, China are at high risk of developing lung cancer with significant occupational characteristics. Tissue samples from these miners presented pathological characteristics, such as fibroplasia in carcinomas, peri-cancerous tissue in lung cancers, and hyperplasia and dysplasia of epithelial cells in peri-cancerous tissue. Carcinomas induced by Yunnan tin mine dust in the animal experiment underwent inflammation, fibroplasia, hyperplasia, dysplasia, and carcinogenesis of epithelial cells. A correlated and synergistic relationship was observed between bronchial epithelial cell transformation and fibroblast activation in vitro induced by mine dust. Fibroblast hyperplasia and activation are important factors that promote the transformation and carcinogenesis of epithelial cells. Our findings suggested that pulmonary fibrosis may increase the risk and promote the occurrence of lung cancer, which can lead to lung fiber hyperplasia.