Visual field and retinal nerve fiber layer comparisons in glaucoma.
Visual field and retinal nerve fiber layer comparisons in glaucoma.
复制标题
青光眼的视野和视网膜神经纤维层比较。
DOI：
10.1001/archopht.1985.01050020057019
复制
发表时间：
1985
影响因子：
--
通讯作者：
K. Wijsman
中科院分区：
文献类型：
--
作者：
P. Airaksinen;S. Drance;G. Douglas;M. Schulzer;K. Wijsman
分别对视网膜神经纤维层（RNFL）的弥漫性和局域性变化进行半定量评分，与OCTOPUS程序JO的49个阈值计算的总体平均视网膜灵敏度和视野指数相关。这些指标已经发展到区分视网膜敏感性的广泛性降低和局部紊乱。RNFL评分与视野功能高度相关。大约50%的视野功能变化可以由RNFL损失评分来解释。线性回归能较好地拟合局部神经纤维损失评分，二次回归能较好地拟合弥漫性神经纤维损失评分。这表明局部神经纤维丢失可能比全身性纤维丢失与局部视野障碍更直接相关，并且在结构改变的出现和视网膜敏感性的全身性降低之间可能存在潜伏期。
Semiquantitative retinal nerve fiber layer (RNFL) scores given separately to diffuse and localized changes of the RNFL were correlated with the overall mean retinal sensitivity and visual field indexes calculated from 49 thresholds of the OCTOPUS program JO. The indexes have been developed to differentiate between generalized reduction and localized disturbances of the retinal sensitivity. The RNFL scores and visual field functions were highly correlated. Approximately 50% of the variation of the visual field functions could be accounted for by the RNFL loss scores. An adequate fit of visual field data on localized nerve fiber loss score was achieved by linear regression, whereas the diffuse nerve fiber loss score was improved by quadratic regression. This suggests that localized nerve fiber loss may be more directly associated with localized visual field disturbances than generalized fiber loss and that there may be a latency between the appearance of structural changes and generalized reduction of retinal sensitivity.