Serious ventricular dysrhythmias after intracoronary papaverine.
Serious ventricular dysrhythmias after intracoronary papaverine.
复制标题
冠状动脉内注射罂粟碱后出现严重的室性心律失常。
DOI：
10.1016/0002-9149(88)90281-0
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
White,CW
中科院分区：
文献类型：
--
作者：
Wilson,RF;White,CW
冠状动脉内注射罂粟碱是一种有效的微血管扩张剂，能够使正常冠状动脉的冠状动脉血流速度短暂增加5倍。1许多研究者最近使用冠状动脉内注射罂粟碱来测量各种疾病的冠状动脉血流储备。2 - 4当我们最初报告使用罂粟碱时，我们注意到患者经常出现短暂的QT间期延长，但当给予10.12 mg罂粟碱时，没有发生显著的心律失常。5在对>300例患者进行冠状动脉内给予罂粟碱后，我们观察到2例严重的室性心律失常发作，这些室性心律失常发作是在冠状动脉内给予小剂量罂粟碱后立即发生的。
Papaverine administered by the intracoronary route is a potent microvascular vasodilator capable of causing a brief 5-fold increase in coronary blood flow velocity in normal coronary arteries.1Many investigators have recently used intracoronary papaverine to measure coronary flow reserve in a variety of diseases.2–4When we originally reported the use of papaverine, we noted that patients often developed transient lengthening of the QT interval, but that no significant arrhythmias occurred when ⩽12 mg of papaverine was administered.5After administering intracoronary papaverine to >300 patients, we observed 2 episodes of serious ventricular dysrhythmias immediately following small doses of intracoronary papaverine.