Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)-report 4: analysis and outcome of scleritis in an East Asian population
Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)-report 4: analysis and outcome of scleritis in an East Asian population
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DOI：
10.1186/s12348-017-0124-5
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发表时间：
2017-02-15
影响因子：
2.9
通讯作者：
Agrawal, Rupesh
中科院分区：
文献类型：
--
作者：
Bin Ismail, Muhammad Amir;Lim, Rachel Hui Fen;Agrawal, Rupesh
背景资料：本研究的目的是评价新加坡三级眼科转诊眼科研究所的眼部自身免疫系统炎症感染研究（OASIS）数据库中的巩膜炎谱。从2200例眼部自身免疫系统炎症感染研究（OASIS）的数据库中，120例巩膜炎患者的临床记录进行了审查。结果：56.6%为女性，平均年龄为48.6 ± 15.9岁。弥漫性前巩膜炎75例（62.5%），弥漫性前巩膜炎25例（20.结节性前巩膜炎7例（5.8%），坏死性前巩膜炎7例（5.8%），后巩膜炎13例（10.8%）。在53.3%的患者中观察到眼部并发症，包括前葡萄膜炎（42.5%）、眼内压升高（12.5%）和角膜受累（11.7%）。自身免疫原因与31例（25.8%）患者相关，10例（8.3%）患者有相关感染病因，远高于高加索研究。53.3%的患者接受了口服皮质类固醇治疗，而26.7%需要免疫抑制剂。结论：感染性病因需要考虑从亚洲起源的巩膜炎患者。在我们的研究和OASIS数据库中，巩膜炎与全身性自身免疫性疾病和眼部并发症相关。
Background: The purpose of this study is to evaluate the spectrum of scleritis from database of Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) at a tertiary eye referral eye institute in Singapore. Clinical records of 120 patients with scleritis from a database of 2200 patients from Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) were reviewed.Results: 56.6% were females, with a mean age of 48.6 +/- 15.9 years. 75 (62.5%) had diffuse anterior scleritis, 25 (20. 8%) had nodular anterior scleritis, 7 (5.8%) had necrotizing anterior scleritis and 13 (10.8%) had posterior scleritis. Ocular complications were observed in 53.3% of patients, including anterior uveitis (42.5%), raised intraocular pressure (12.5%), and corneal involvement (11.7%). Autoimmune causes were associated with 31 (25.8%) of patients, and 10 (8.3%) patients had an associated infective etiology, much higher than Caucasian studies. 53.3% of patients were treated with oral corticosteroids while 26.7% required immunosuppressives.Conclusions: Infective etiology needs to be considered in patients of scleritis from Asian origin. In our study and in OASIS database, scleritis was associated with systemic autoimmune disease and ocular complications.