Synthesis of Multifunctional Polymers through the Ugi Reaction for Protein Conjugation
Synthesis of Multifunctional Polymers through the Ugi Reaction for Protein Conjugation
复制标题
DOI：
10.1021/ma501385m
复制
发表时间：
2014-08
期刊：
影响因子：
5.5
通讯作者：
Bin Yang;Yuan Zhao;Shiqi Wang;Yaling Zhang;Changkui Fu;Yen Wei;Lei Tao
中科院分区：
文献类型：
--
作者：
Bin Yang;Yuan Zhao;Shiqi Wang;Yaling Zhang;Changkui Fu;Yen Wei;Lei Tao
Ugi反应作为一种多组分点击反应，已被用于合成一系列多功能聚乙二醇化试剂，并成功地将这些PEG衍生物偶联到蛋白质表面，生成相应的多功能蛋白质-聚合物偶联物，表明Ugi反应在聚乙二醇化领域具有广阔的应用前景。
The Ugi reaction has been utilized as a multicomponent click reaction to efficiently synthesize a series of multifunctional PEGylation agents, and those PEG derivatives were successfully conjugated on a protein surface to generate corresponding multifunctional protein–polymer conjugates, indicating the promising potential of the Ugi reaction in the field of PEGylation.