A new flavonoid from the aerial parts of Andrographis paniculata
A new flavonoid from the aerial parts of Andrographis paniculata
复制标题
穿心莲地上部分的一种新黄酮类化合物
DOI：
10.1080/14786419.2013.856907
复制
发表时间：
2014-02-01
影响因子：
2.2
通讯作者：
Qiu, Feng
中科院分区：
文献类型：
--
作者：
Chen, Li-Xia;He, Hao;Qiu, Feng
从穿心莲（AndrographispaniculataNees）地上部分分得一个新黄酮类化合物，即7，8-二甲氧基-2-羟基-5-O-β-d-吡喃葡萄糖氧基黄酮（1），沿着已知的15个黄酮类化合物（2-16）。根据化学和光谱分析鉴定了它们的结构。大多数化合物具有不常见的O-取代模式，包括5-、7-、8-、2-、3-、4-和5-O-取代基。研究了这些黄酮类化合物对人白血病HL-60细胞增殖的抑制作用。其中，13是最有活性的，显示出有效的抗增殖活性，IC_（50）为3.50M。对这些化合物的构效关系进行了讨论。
A new flavonoid, 7,8-dimethoxy-2-hydroxy-5-O--d-glucopyranosyloxyflavone (1), along with 15 known flavonoids (2-16), was isolated from the aerial parts of Andrographis paniculata Nees. Their structures were elucidated on the basis of chemical and spectroscopic analyses. Most of them have uncommon O-substitution patterns involving 5-, 7-, 8-, 2-, 3-, 4- and 5-O-substituents. The antiproliferative effects of these flavonoids against human leukaemia HL-60 cells were investigated. Among them, 13 was the most active, displaying potent antiproliferative activity with IC50 of 3.50M. The structure-activity relationships of these isolated compounds were discussed.