ABNORMAL GLYCINE BETAINE CONTENT OF THE BLOOD AND URINE OF DIABETIC AND RENAL PATIENTS
ABNORMAL GLYCINE BETAINE CONTENT OF THE BLOOD AND URINE OF DIABETIC AND RENAL PATIENTS
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DOI：
10.1016/0009-8981(94)90090-6
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发表时间：
1994-10-14
影响因子：
5
通讯作者：
CHAMBERS, ST
中科院分区：
文献类型：
--
作者：
LEVER, M;SIZELAND, PCB;CHAMBERS, ST
在正常人血浆中，肾渗透剂甘氨酸甜菜碱的浓度通常在20 - 70 μ mol/l之间，成年男性（中位数44 μ mol/l）高于女性（34 μ mol/l）。肾脏疾病患者的浓度较低（中位数为28 μ mol/l），糖尿病患者的浓度正常。尿中甘氨酸甜菜碱的排泄量没有性别差异，在肾脏疾病和糖尿病中经常升高（中位数：正常，6.2，肾脏12.3和糖尿病，39.7 mmol/mol肌酐）。糖尿病的升高与已知的肾脏疾病没有强相关性，也与尿微量白蛋白或血浆肌酐无关。与糖化血红蛋白无相关性。与另一种肾脏渗透剂山梨醇的排泄量正相关，在糖尿病受试者中具有高度显著性。糖尿病组血浆甜菜碱与尿微量白蛋白呈显著负相关。
In normal human plasma the concentrations of the renal osmolyte, glycine betaine, are usually between 20 and 70 mu mol/l, in adult males (median 44 mu mol/l) higher than in females 34 mu mol/l). Concentrations are lower in renal disease (median 28 mu mol/l) and normal in diabetes. Urinary excretion of glycine betaine shows no sex difference and is frequently elevated both in renal disease and in diabetes (medians: normal, 6.2, renal 12.3 and diabetes, 39.7 mmol/mol creatinine). The elevation in diabetes does not strongly correlate with known renal disease, nor with either urinary microalbumin or plasma creatinine. There is no correlation with glycated haemoglobin. The positive correlation with the excretions of another renal osmolyte, sorbitol, was highly significant in diabetic subjects. In the diabetic group there was also a significant negative correlation between plasma glycine betaine and urine microalbumin.