Retinal vascular bed area on ultra-wide field fluorescein angiography indicates the severity of diabetic retinopathy
Retinal vascular bed area on ultra-wide field fluorescein angiography indicates the severity of diabetic retinopathy
复制标题
超广角荧光素血管造影的视网膜血管床面积可提示糖尿病视网膜病变的严重程度
DOI：
10.1136/bjophthalmol-2020-317488
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发表时间：
2021-04-07
影响因子：
4.1
通讯作者：
Ip, Michael S.
中科院分区：
文献类型：
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作者：
Fan, Wenying;Uji, Akihito;Ip, Michael S.
目的对糖尿病视网膜病变（DR）视网膜血管床面积（RVBA）进行立体投影超宽场（UWF）荧光素血管造影（FA），以平方毫米为单位定量。方法前瞻性观察性研究。来自DAVE （NCT01552408）和RECOVERY （NCT02863354）研究的80只患有DR的眼睛的基线Optos 200Tx UWF FA图像在Doheny图像阅读中心进行了三维投影，以调整周边失真。使用早期FA框架提取视网膜血管作为计算RVBA的掩模。使用制造商提供的软件，以平方毫米为单位自动计算视网膜血管的像素。结果80只糖尿病眼中有18只因图像质量和对比度不足无法从背景荧光中自动提取视网膜血管而被排除。其余62只眼纳入最终分析。与年龄匹配和性别匹配的正常对照相比，患有DR的眼睛在整个视网膜上具有更高的全局RVBA (p
Aims To quantify retinal vascular bed area (RVBA) in square millimetres on stereographically projected ultra-wide field (UWF) fluorescein angiography (FA) in eyes with diabetic retinopathy (DR). Methods A prospective, observational study. Baseline Optos 200Tx UWF FA images of 80 eyes with DR from the DAVE (NCT01552408) and RECOVERY (NCT02863354) studies were stereographically projected at the Doheny Image Reading Center to adjust for peripheral distortion. The early-phase FA frame was used to extract the retinal vasculature as a mask for calculating RVBA. The pixels of the retinal vasculature were automatically computed in square millimetres using manufacturer-provided software. Results Eighteen of 80 diabetic eyes were excluded because image quality and contrast were insufficient for automatic extraction of the retinal vasculature from the background fluorescence. The remaining 62 eyes were included in the final analysis. In comparison with age-matched and sex-matched normal controls, eyes with DR had a higher global RVBA for the entire retina (p