The intergenerational transmission of suicidal behavior: an offspring of siblings study.
The intergenerational transmission of suicidal behavior: an offspring of siblings study.
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自杀行为的代际传递：兄弟姐妹的后代研究。
DOI：
10.1038/s41398-020-0850-6
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发表时间：
2020
影响因子：
6.8
通讯作者：
D'Onofrio,BrianM
中科院分区：
文献类型：
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作者：
O'Reilly,LaurenM;Kuja-Halkola,Ralf;Rickert,MartinE;Class,QuetzalA;Larsson,Henrik;Lichtenstein,Paul;D'Onofrio,BrianM
我们考察了与父母自杀行为(自杀企图或自杀)相关的遗传因素、测量的协变量和环境因素在多大程度上解释了父母和子女之间的自杀行为之间的联系。我们使用了1973年至2001年出生的2,762,883名瑞典后代。我们对同父异母和同父异母的子女进行了两组分析：(1)分析母亲自杀行为的数量行为遗传模型；(2)分析母亲和父亲自杀行为的固定效应Cox比例风险模型。这些分析还调整了许多测量的协变量(例如，父母严重的精神疾病)。数量行为遗传学分析发现，29.2%(95%可信区间[CI]，5.29，53.12%)的代际关联是由于与母亲自杀行为相关的环境因素，其余的是遗传因素。对父母行为健康问题的统计调整部分减弱了环境关联；然而，结果不再具有统计学意义。考克斯风险模型类似地发现，如果母亲自杀未遂/死亡，子女自杀行为的风险增加2.74倍[95%CI，2.67，2.83]。在调整了家庭因素和测量的协变量后，不和谐的同父异母兄弟姐妹(HR，1.57[95%CI，1.45，1.71])和完全兄弟姐妹(HR，1.62[95%CI，1.57，1.67])的后代的关联性减弱，但仍保持升高。考克斯风险模型显示了父亲和子女自杀行为之间的相似模式。这项研究发现，自杀行为的代际传递很大程度上是由于共同的遗传因素，以及与父母行为健康问题相关的因素和与父母自杀行为相关的环境因素。
We examined the extent to which genetic factors shared across generations, measured covariates, and environmental factors associated with parental suicidal behavior (suicide attempt or suicide) account for the association between parental and offspring suicidal behavior. We used a Swedish cohort of 2,762,883 offspring born 1973–2001. We conducted two sets of analyses with offspring of half- and full-siblings: (1) quantitative behavior genetic models analyzing maternal suicidal behavior and (2) fixed-effects Cox proportional hazard models analyzing maternal and paternal suicidal behavior. The analyses also adjusted for numerous measured covariates (e.g., parental severe mental illness). Quantitative behavior genetic analyses found that 29.2% (95% confidence interval [CI], 5.29, 53.12%) of the intergenerational association was due to environmental factors associated with exposure to maternal suicidal behavior, with the remainder due to genetic factors. Statistical adjustment for parental behavioral health problems partially attenuated the environmental association; however, the results were no longer statistically significant. Cox hazard models similarly found that offspring were at a 2.74-fold increased risk [95% CI, 2.67, 2.83]) of suicidal behavior if their mothers attempted/died by suicide. After adjustment for familial factors and measured covariates, associations attenuated but remained elevated for offspring of discordant half-siblings (HR, 1.57 [95% CI, 1.45, 1.71]) and full-siblings (HR, 1.62 [95% CI, 1.57, 1.67]). Cox hazard models demonstrated a similar pattern between paternal and offspring suicidal behavior. This study found that the intergenerational transmission of suicidal behavior is largely due to shared genetic factors, as well as factors associated with parental behavioral health problems and environmental factors associated with parental suicidal behavior.