Complete Genome Sequence of a J Subgroup Avian Leukosis Virus Isolated from Local Commercial Broilers
Complete Genome Sequence of a J Subgroup Avian Leukosis Virus Isolated from Local Commercial Broilers
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从当地商业肉鸡中分离出 J 亚组禽白血病病毒的完整基因组序列
DOI：
10.1128/jvi.02009-12
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发表时间：
2012-11-01
影响因子：
5.4
通讯作者：
Xie, Qingmei
中科院分区：
文献类型：
--
作者：
Li, Hongxin;Xue, Chunyi;Xie, Qingmei
摘要J亚群禽白血病病毒（ALV-J）GDKP 1202分离株于2012年从中国广东省一只50日龄本地黄羽商品肉鸡中分离。在这里，我们报告了GDKP 1202分离株的全基因组序列，该分离株在商业肉鸡中引起高死亡率，严重的生长抑制，胸腺萎缩和肝脏肿大。在GDKP 1202基因组中发现了一个新的c-myb结合位点（5′-GGCACCTCC-3′）。这些发现将为ALV-J基因组的分子特征和致病性提供更多的见解。
ABSTRACT Subgroup J avian leukosis virus (ALV-J) isolate GDKP1202 was isolated from a 50-day-old local yellow commercial broiler in the Guangdong province of China in 2012. Here we report the complete genomic sequence of the GDKP1202 isolate, which caused high mortality, serious growth suppression, thymic atrophy, and liver enlargement in commercial broilers. A novel potential binding site (5′-GGCACCTCC-3′) for c-myb was identified in the GDKP1202 genome. These findings will provide additional insights into the molecular characteristics in the genomes and pathogenicity of ALV-J.