Biology of chronic graft-vs-host disease: Immune mechanisms and progress in biomarker discovery.
Biology of chronic graft-vs-host disease: Immune mechanisms and progress in biomarker discovery.
复制标题
DOI：
10.5500/wjt.v6.i4.608
复制
发表时间：
2016-12-24
期刊：
影响因子：
--
通讯作者：
Presland RB
中科院分区：
文献类型：
--
作者：
Presland RB
慢性移植物抗宿主病（cGVHD）是异基因造血干细胞移植后长期发病和死亡的主要原因。它表现为一种慢性炎症和类硬皮病自身免疫性疾病，最常影响皮肤、口腔粘膜、肝脏、眼睛和胃肠道。临床和动物研究均表明，多种T细胞亚群（包括Th1、Th2、Th17、滤泡辅助性T细胞和调节性T细胞）在cGVHD的发生和发展中发挥一定作用; B细胞也在疾病中发挥重要作用，包括产生HY抗体和核抗原，可引起严重的组织损伤。由不同类型的免疫细胞产生的一系列细胞因子和趋化因子也介导组织炎症和cGVHD靶组织如皮肤和口腔的损伤。许多这些相同的免疫调节剂已被研究作为候选cGVHD生物标志物。最近的研究表明，这些生物标志物中的一些可能有助于确定疾病预后和规划cGVHD患者的长期临床随访。
Chronic graft-vs-host disease (cGVHD) is the leading cause of long-term morbidity and mortality following allogeneic hematopoietic stem cell transplantation. It presents as a chronic inflammatory and sclerotic autoimmune-like condition that most frequently affects the skin, oral mucosa, liver, eyes and gastrointestinal tract. Both clinical and animal studies have shown that multiple T cell subsets including Th1, Th2, Th17, T follicular helper cells and regulatory T-cells play some role in cGVHD development and progression; B cells also play an important role in the disease including the production of antibodies to HY and nuclear antigens that can cause serious tissue damage. An array of cytokines and chemokines produced by different types of immune cells also mediate tissue inflammation and damage of cGVHD target tissues such as the skin and oral cavity. Many of these same immune regulators have been studied as candidate cGVHD biomarkers. Recent studies suggest that some of these biomarkers may be useful for determining disease prognosis and planning long-term clinical follow-up of cGVHD patients.