FLNA and PGK1 are Two Potential Markers for Progression in Hepatocellular Carcinoma
FLNA and PGK1 are Two Potential Markers for Progression in Hepatocellular Carcinoma
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DOI：
10.1159/000327946
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发表时间：
2011-01-01
影响因子：
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通讯作者：
Zhou, Qin
中科院分区：
文献类型：
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作者：
Ai, Jianzhong;Huang, Huizhe;Zhou, Qin
背景/目标：肝细胞癌（Hepatocellular carcinoma，HCC）是世界上最致命的疾病之一，转移和复发是长期影响HCC治疗的重要因素。迄今为止，肝癌转移的预后仍未改善。近年来，一些与肝癌转移和侵袭相关的蛋白质被鉴定出来，但有效的标志物仍有待阐明。研究方法：本研究采用比较蛋白质组学的方法，对两株分别具有低转移潜能和高转移潜能的肝癌细胞系MHCC 97 L和HCCLM 9中差异表达的蛋白质进行了研究。结果如下：我们的研究结果表明细丝蛋白A（Filamin A，FLNA）和磷酸甘油酸激酶1（phosphoglycerate kinase 1，PGK 1）是两个显著差异表达的蛋白，在HCCLM 9细胞中高表达，可能影响肝癌细胞的转移。结论：结合mRNA水平表达的确认，我们建议使用FLNA和PGK 1作为HCC进展的潜在标志物。版权所有（C）2011 S. Karger AG，巴塞尔
Background/Aims: Hepatocellular carcinoma (HCC) is one of the most deadly diseases; metastasis and recurrence are the most important factors that affect the therapy of HCC chronically. Until now, the prognosis for the metastasis of HCC had not improved. Recently, several proteins that are related to metastasis and invasion of HCC were identified, but the effective markers still remain to be elucidated. Methods: In this study, comparative proteomics was used to study the differentially expressed proteins in two HCC cell lines MHCC97L and HCCLM9, which have low and high metastatic potentials, respectively. Results: Our findings indicated that filamin A (FLNA) and phosphoglycerate kinase 1 (PGK1) were two significantly differentially expressed proteins, with high expression in HCCLM9 cells, and may influence the metastasis of HCC cells. Conclusion: Taken together with the confirmation of expression on the mRNA level, we propose the use of FLNA and PGK1 as potential markers for the progression of HCC. Copyright (C) 2011 S. Karger AG, Basel