Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid
Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid
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DOI：
10.1016/j.ejmech.2010.07.038
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发表时间：
2010-10-01
影响因子：
6.7
通讯作者：
Wang, Shifa
中科院分区：
文献类型：
--
作者：
Gu, Wen;Wang, Shifa
以7-氧代脱氢松香酸甲酯为原料，与取代苯肼反应，合成了一系列1H-二苯并[a，c]咔唑衍生物，其结构经IR，1H-1 NMR，MS和元素分析确证。对4种细菌（枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌和荧光假单胞菌）和3种真菌（红色毛癣菌、白色念珠菌和尼日尔曲霉）进行了体外抗菌活性测定，其中6d、6 e、6 f和6 m表现出明显的抗菌活性，6 e和6 m也表现出一定的抗真菌活性。特别是6d对B具有较强的抗菌活性。枯草芽孢杆菌与阳性对照相当。(C)2010 Elsevier Masson SAS保留所有权利。
A series of novel 1H-dibenzo[a,c]carbazole derivatives were synthesized in good yield through reaction of methyl 7-oxo-dehydroabietate with a variety of substituted phenylhydrazines The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, MS spectral studies and elemental analysis. All compounds were investigated for their activity against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens) and three fungi (Trichophyton rubrum, Candida albicans and Aspergillus niger) Among the compound tested, 6d, 6e, 6f and 6m exhibited pronounced antibacterial activities and 6e and 6m also showed moderate antifungal activities. Particularly, 6d exhibited stronger antibacterial activity against B. subtilis comparable to positive control. (C) 2010 Elsevier Masson SAS All rights reserved.