Drosophila as a Model to Study the Blood-Brain Barrier
Drosophila as a Model to Study the Blood-Brain Barrier
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DOI：
10.1007/978-1-4939-8946-1_10
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发表时间：
2018-12
期刊：
影响因子：
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通讯作者：
Cameron R. Love;B. Dauwalder
中科院分区：
文献类型：
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作者：
Cameron R. Love;B. Dauwalder
果蝇的血脑屏障（BBB）在结构和功能上与脊椎动物的BBB非常相似。由于这种生物体的遗传工具，果蝇特别适合研究bbb生理学和功能，与哺乳动物功能高度相关。在本章中，我们将讨论靶向策略，具体标记和操作血脑屏障细胞，如何测试血脑屏障的完整性，以及方法来分离单血脑屏障细胞。
TheDrosophilablood-brain barrier (BBB) has been shown to be largely analogous in structure and function to the vertebrate BBB. Thanks to the genetic tools available for this organism,Drosophilais uniquely suited to study bbb physiology and function, with high relevance for mammalian function. In this chapter we discuss targeting strategies to specifically mark and manipulate BBB cells, how to test BBB integrity, and methods to isolate single-BBB cells.