A myocardial lineage derives from Tbx18 epicardial cells
A myocardial lineage derives from Tbx18 epicardial cells
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DOI：
10.1038/nature06969
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发表时间：
2008-07-03
期刊：
影响因子：
64.8
通讯作者：
Evans, Sylvia M.
中科院分区：
文献类型：
--
作者：
Cai, Chen-Leng;Martin, Jody C.;Evans, Sylvia M.
了解心脏前体细胞的起源和作用对于阐明先天性和获得性心脏病的发病机制很重要。此外，对心肌祖细胞的操纵有可能为各种心肌疾病提供基于细胞的修复策略(3)。在这里，我们报告了在小鼠身上鉴定出一种以前未知的来自心外膜器官的心肌细胞谱系。这些祖细胞表达T-box转录因子TBX18，迁移到心脏外表面形成心外膜，然后对室间隔、心房和室壁的心肌细胞做出实质性贡献。表达TBX18的心脏祖细胞还可分化为心脏成纤维细胞和冠状动脉平滑肌细胞。TBX18心外膜前细胞的多能性为应用这些前体细胞影响心脏修复和再生提供了理论框架。
Understanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases(1,2). Moreover, manipulation of cardiac myocyte progenitors has potential for cell- based repair strategies for various myocardial disorders(3). Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T- box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Tbx18- expressing cardiac progenitors also give rise to cardiac fibroblasts and coronary smooth muscle cells. The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.