Insights into Potential Mechanisms of Injury and Treatment Targets in COVID-19, SARS-Cov-2 Infection
Insights into Potential Mechanisms of Injury and Treatment Targets in COVID-19, SARS-Cov-2 Infection
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DOI：
10.15344/2456-8007/2020/147
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发表时间：
2020-06
期刊：
影响因子：
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通讯作者：
Angelina Zhyvotovska;D. Yusupov;R. Foronjy;Mohammed Nakeshbandi;Samy I McFarlane;M. Salifu
中科院分区：
文献类型：
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作者：
Angelina Zhyvotovska;D. Yusupov;R. Foronjy;Mohammed Nakeshbandi;Samy I McFarlane;M. Salifu
严重急性呼吸系统综合征冠状病毒（SARS-CoV-2）是现代最严重的大流行。该疾病于2020年1月在中国湖北省武汉市首次报道，自那时起，它已在全球传播。鉴于该病毒的迅速传播及其给横扫各地的卫生保健系统带来的负担，有必要对目前对SARS-CoV-2感染中器官衰竭发病机制的理解进行简要描述，同时承认还有更多尚未发现。这篇综述不仅将为床边的决策提供信息，而且将有助于阐明研究的潜在治疗靶点。我们检索了迄今为止可用的文献，并以高度图解的方式介绍了肺部、心脏和肾脏中SARS-CoV-2感染的发病率和死亡率增加的病理生理学，这对临床医生、研究人员和学生都很容易理解。
The severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, is the most serious pandemic in modern times. The disease was first reported in January of 2020 in China’s city of Wuhan, Hubei province, and since then it has spread worldwide. Given the rapid spread of the virus and the burden it has taken on the healthcare systems it has swept through, there is the need for a concise description of current understanding of the pathogenesis of organ failure in SARS-CoV-2 infection while acknowledging that more is yet to be uncovered. This review will not only inform decision making at the bedside but will also help illustrate potential therapeutic targets for research. We searched the available literature to-date, and present the pathophysiology underlying increased morbidity and mortality of SARS-CoV-2 infection in the lungs, heart and kidneys in a highly illustrated presentation that is easy-to-understand for the clinician, researcher, and student alike.