FEEDING-RELATED CIRCADIAN VARIATION IN TELE-METHYLHISTAMINE LEVELS OF MOUSE AND RAT BRAINS
FEEDING-RELATED CIRCADIAN VARIATION IN TELE-METHYLHISTAMINE LEVELS OF MOUSE AND RAT BRAINS
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DOI：
10.1111/j.1471-4159.1987.tb02898.x
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发表时间：
1987-08-01
影响因子：
4.7
通讯作者：
SAEKI, K
中科院分区：
文献类型：
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作者：
OISHI, R;ITOH, Y;SAEKI, K
研究了小鼠和大鼠适应12小时光/暗交替周期(0600点亮)后，脑组织中组胺(HA)和端甲基组胺(t-MH)水平的昼夜变化。虽然脑内HA水平没有明显的昼夜波动，但其主要代谢物t-MH的水平表现出明显的昼夜变化。在小鼠中，从1200点到18点，t-MH水平约为80 ng/g，但从24点到次日凌晨6点，t-MH水平约高出两倍。在大鼠中，t-MH水平在24到28 ng/gt0600和1200之间，在1800时略有增加，并在2400达到峰值，是光照期间水平的两倍。在随后的3h内，t-MH水平又迅速下降，从1200开始禁食的小鼠，在黑暗期间t-MH水平没有升高。当小鼠在禁食24小时后以1200℃喂养时，观察到1800℃时t-MH水平显著升高。小鼠和大鼠血浆中HA和t-MH水平无明显昼夜变化。这些结果表明，脑中t-MH水平的昼夜变化与摄食和随后t-MH从脑中清除的可能变化和/或脑中HA的周转有关。在评估脑内HA动态时，这一现象应该得到应有的重视。
Circadian changes in the brain histamine (HA) and tele-methylhistamine (t-MH) levels were studied in mice and rats after adaptation to an alternating 12-h light/dark cycle (lights on at 0600). Although there was no significant circadian fluctuation of the brain HA levels, the levels of t-MH, a major metabolite of brain HA, showed a marked circadian variation. In mice, the t-MH levels were about 80 ng/g from 1200 to 1800 but about two times higher values were obtained from 2400 to 0600 of the next morning. In rats, the t-MH levels ranged from 24 to 28 ng/gt 0600 and 1200, slightly increased at 1800, and reached at 2400 a peak twice as high as the levels seen during the light period. The t-MH levels again rapidly decreased during the subsequent 3 h. In mice fasted from 1200, the t-MH levels did not increase during the period of darkness. When mice were fed at 1200 after a 24-h fast, a significant increase in the t-MH levels was observed at 1800. There was no significant circadian variation of the HA and t-MH levels in the plasma of mice and rats. These results suggest that circadian variation in brain t-MH levels is related to feeding and possible subsequent changes in elimination of t-MH from the brain and/or turnover of HA in the brain. This phenomenon should be given due attention when HA dynamics in the brain are being assessed.