Development and Initial Validation of a Frailty Score for Pediatric Patients with Congenital and Acquired Heart Disease.
Development and Initial Validation of a Frailty Score for Pediatric Patients with Congenital and Acquired Heart Disease.
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先天性和后天性心脏病儿科患者衰弱评分的制定和初步验证。
DOI：
10.1007/s00246-022-03045-1
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发表时间：
2024
影响因子：
1.6
通讯作者：
White,DavidA
中科院分区：
文献类型：
--
作者：
Studyvin,Sarah;Birnbaum,BrianF;Staggs,VincentS;Gross-Toalson,Jami;Shirali,Girish;Panchangam,Chaitanya;White,DavidA
虚弱是一种多维的临床综合征，与发病率和死亡率的增加以及生活质量的下降有关。患有心脏病(HD)的儿童/青少年在每个脆弱领域的表现都比非HD同龄人差得多。本研究旨在建立一个可应用于HD儿童/青少年的综合脆弱评分(CFS)，并评估CFS与预后之间的关系。从2016年到2017年(基线)收集了30例患有HD的儿童和青少年(n= )(73%为单心室，20%为心力衰竭，7%为肺动脉高压)。在基线时，使用儿科验证的测量方法评估了五个脆弱领域：(1)缓慢：6分钟步行试验；(2)无力：握力；(3)疲劳：PedsQL多维疲劳量表；(4)身体成分：三头肌皮褶厚度；(5)体力活动问卷。每个领域的脆弱分数(范围 = 0-5)根据z分数或原始问卷分数进行分配，并相加得到CFS(0 = 最弱；25 = 最弱)。采用非参数自举法确定慢性疲劳综合征与2.2年 ± 0.2年的横断面结果变化之间的相关性。平均中心频率为12 5 ± 3 5。在对基线数据的横断面分析中，CFs与NYHA分级、辅助专家数量、总处方药、心力衰竭用药/天、运动试验得出的变时性指数和预测VO2峰值的百分比以及儿童与父母之间的相关性(|r|≥ 0.30)。在随访中，CFs与心力衰竭药物数量的增加相关(r= 0.31)。CFS与青年心脏病患者的横断面结果相关。由于缺乏追踪，纵向分析因样本量小而受到限制。
Frailty is a multi-dimensional clinical syndrome that is associated with increased morbidity and mortality and decreased quality of life. Children/adolescents with heart disease (HD) perform significantly worse for each frailty domain compared to non-HD peers. Our study aimed to create a composite frailty score (CFS) that can be applied to children/adolescents with HD and evaluate associations between the CFS and outcomes. Children and adolescents (n= 30) with HD (73% single ventricle, 20% heart failure, 7% pulmonary hypertension) were recruited from 2016 to 2017 (baseline). Five frailty domains were assessed at baseline using measures validated for pediatrics: (1) Slowness: 6-min walk test; (2) Weakness: handgrip strength; (3) Fatigue: PedsQL Multi-dimensional Fatigue Scale; (4) Body composition: triceps skinfold thickness; and (5) Physical activity questionnaire. Frailty points per domain (range = 0–5) were assigned based onz-scores or raw questionnaire scores and summed to produce a CFS (0 = least frail; 25 = most frail). Nonparametric bootstrapping was used to identify correlations between CFS and cross-sectional change in outcomes over 2.2 ± 0.2 years. The mean CFS was 12.5 ± 3.5. In cross-sectional analyses of baseline data, correlations (|r|≥ 0.30) were observed between CFS and NYHA class, the number of ancillary specialists, total prescribed medications, heart failure medications/day, exercise test derived chronotropic index and percent predicted VO2peak, and between child and parent proxy PEDsQL. At follow-up, CFS was correlated with an increase in the number of heart failure medications (r= 0.31). CFS was associated with cross-sectional outcomes in youth with heart disease. Longitudinal analyses were limited by small sample sizes due to loss to follow-up.
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先天性心脏病成人中心脏和非心脏慢性发病率增加
影响因子：
--
作者：
Doron Portal;R. Hirsch;M. Benderly
通讯作者：
M. Benderly
DOI：
10.1186/2049-3258-72-47
发表时间：
2014
期刊：
Archives of public health = Archives belges de sante publique
影响因子：
--
作者：
Bervoets L;Van Noten C;Van Roosbroeck S;Hansen D;Van Hoorenbeeck K;Verheyen E;Van Hal G;Vankerckhoven V
通讯作者：
Vankerckhoven V
影响因子：
3.7
作者：
Voss C;Dean PH;Gardner RF;Duncombe SL;Harris KC
通讯作者：
Harris KC
影响因子：
13.1
作者：
Buta BJ;Walston JD;Godino JG;Park M;Kalyani RR;Xue QL;Bandeen-Roche K;Varadhan R
通讯作者：
Varadhan R
影响因子：
24
作者：
Atz AM;Zak V;Mahony L;Uzark K;D'agincourt N;Goldberg DJ;Williams RV;Breitbart RE;Colan SD;Burns KM;Margossian R;Henderson HT;Korsin R;Marino BS;Daniels K;McCrindle BW;Pediatric Heart Network Investigators
通讯作者：
Pediatric Heart Network Investigators