Medications and verbal memory impairment in schizophrenia:: the role of anticholinergic drugs
Medications and verbal memory impairment in schizophrenia:: the role of anticholinergic drugs
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DOI：
10.1017/s0033291703008900
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发表时间：
2004-02-01
影响因子：
6.9
通讯作者：
Gorman, JM
中科院分区：
文献类型：
--
作者：
Brébion, G;Bressan, RA;Gorman, JM
背景。我们希望评估三种药物对精神分裂症患者言语记忆障碍的影响。48名精神分裂症患者和40名健康对照者接受了一系列言语记忆任务，包括自由回忆、识别和短期记忆广度。所有病人都在服用抗精神病药物。服用抗胆碱能药物（苯托品）24例，服用苯二氮卓类药物30例。39人的子样本有抑郁症状的临床评分。对该亚样本的记忆测量结果进行回归分析，包括阴性症状、抑郁、抗精神病药物类型（常规对照）。非典型)、苯二氮卓类药物和抗胆碱能药物作为预测因素。抗精神病药物类型对记忆缺陷没有显著贡献，苯二氮卓类药物的使用贡献很小。然而，抗胆碱能药物是记忆障碍的预测因子，特别是在语义组织方面。补充分析显示，服用任何类型的抗胆碱能药物（苯托品和/或抗精神病药物）的患者在反映自由回忆效率和语义组织的措施上相对于其他患者显着受损。具有抗胆碱能活性的药物是导致精神分裂症患者言语记忆缺陷的主要药物。这些药物似乎通过阻碍编码时的语义组织起作用。
Background. We wished to assess the effect of three types of medication on verbal memory impairments in schizophrenia.Method. Forty-eight patients with schizophrenia and 40 healthy control subjects underwent a battery of verbal memory tasks, including free recall, recognition and short-term memory span. All the patients were on antipsychotic medication. In addition, 24 were taking anticholinergic drugs (benztropine) and 30 were taking benzodiazepines. A subsample of 39 had clinical ratings for depressive symptoms. Regression analyses were conducted on the memory measures in this subsample, with negative symptoms, depression, type of antipsychotic medication (conventional nu. atypical), benzodiazepines and anticholinergic drugs as predictors.Results. Type of antipsychotic medication made no significant contribution to memory deficits and benzodiazepine use made very little contribution. However, anticholinergic medication was a predictor of memory impairment, especially with regard to semantic organization. Complementary analyses revealed that patients taking any type of drug with anticholinergic activity (benztropine and/or antipsychotic agents) were significantly impaired relative to the other patients on measures reflecting free recall efficiency and semantic organization.Conclusions. Drugs with anticholinergic activity are the major pharmacological agents that contribute to the verbal memory deficit observed in patients with schizophrenia. These drugs appear to act by impeding semantic organization at encoding.