Mechanism and therapeutic strategies of depression after myocardial infarction
Mechanism and therapeutic strategies of depression after myocardial infarction
复制标题
心肌梗死后抑郁的机制及治疗策略
DOI：
10.1007/s00213-021-05784-0
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Cheng Yuanyuan
中科院分区：
文献类型：
--
作者：
Yang Ying;Li Xuping;Chen Sixuan;Xiao Mingzhu;Liu Zhongqiu;Li Jingyan;Cheng Yuanyuan
抑郁症是与心肌梗死（MI）预后相关的重要因素。心肌梗死患者患抑郁症的风险也较高。尽管心肌梗死后抑郁问题已成为临床关注的问题，但心肌梗死后抑郁的分子机制仍不清楚，一些建议的策略并未取得理想的效果，例如选择性5-羟色胺再摄取抑制剂。本文总结并讨论了心肌梗死后抑郁症的发生机制，如5-羟色胺（5-HT）功能障碍、下丘脑-垂体-肾上腺（HPA）轴功能改变、肠道菌群失衡、外泌体信号转导和炎症等。此外，我们还提供了治疗的简洁概述，以及一些有前途的分子，特别是来自天然产物的用于治疗心肌梗死后抑郁症的分子。
Depression resulted as an important factor associated with the myocardial infarction (MI) prognosis. Patients with MI also have a higher risk for developing depression. Although the issue of depression after MI has become a matter of clinical concern, the molecular mechanism underlying depression after MI remains unclear, whereby several strategies suggested have not got ideal effects, such as selective serotonin reuptake inhibitors. In this review, we summarized and discussed the occurrence mechanism of depression after MI, such as 5-hydroxytryptamine (5-HT) dysfunction, altered hypothalamus-pituitary-adrenal (HPA) axis function, gut microbiota imbalance, exosomal signal transduction, and inflammation. In addition, we offered a succinct overview of treatment, as well as some promising molecules especially from natural products for the treatment of depression after MI.