Effect of orally administered omeprazole on abomasal luminal pH in dairy calves fed milk replacer
Effect of orally administered omeprazole on abomasal luminal pH in dairy calves fed milk replacer
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DOI：
10.1111/j.1439-0442.2005.00715.x
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发表时间：
2005-06-01
期刊：
影响因子：
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通讯作者：
Misk, NA
中科院分区：
文献类型：
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作者：
Ahmed, AF;Constable, PD;Misk, NA
本研究的目的是确定口服质子泵抑制剂奥美拉唑是否会增加饲喂代乳剂的犊牛的皱胃腔pH。4头经皱胃体插管的雄性犊牛哺乳代乳器(60ml/kg体重，每12h一次)，分别以非肠道包被的奥美拉唑(4 mg/kg体重，每24小时一次)糊剂形式饲喂，连续5天。用微型玻璃pH电极连续测定皱胃腔pH值。奥美拉唑给药第1天，24小时平均pH值由2.89升至4.17，差异有统计学意义(P<；0.05)。奥美拉唑用药第2、3、4、5天的平均24 h pH分别为3.85、4.02、3.97和3.39。我们的结论是，口服非肠溶包被的奥美拉唑提高了饲喂牛奶代用品的犊牛的皱胃腔pH，但这种影响可能会随着时间的推移而降低。
The objective of this study was to determine whether oral administration of omeprazole, a proton-pump inhibitor, increased abomasal luminal pH in calves fed milk replacer. Four male dairy calves with cannulae in the abomasal body suckled milk replacer (60 ml/kg body weight every 12 h) and were administered a non-enteric-coated omeprazole (4 mg/kg body weight every 24 h) in a paste formulation for five successive days. Abomasal luminal pH was continuously measured using miniature glass pH electrodes. On the first day of omeprazole administration, there was a significant (P < 0.05) increase in mean 24-h pH from 2.89 to 4.17. The mean 24-h pH on days 2, 3, 4 and 5 of omeprazole administration were 3.85, 4.02, 3.97 and 3.39 respectively. We conclude that oral administration of non-enteric-coated omeprazole increased abomasal luminal pH in calves fed milk replacer, but that the effect may decrease over time.