Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy
Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy
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DOI：
10.1161/hy0302.105221
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发表时间：
2002-03-01
期刊：
影响因子：
8.3
通讯作者：
Kawarabayashi, T
中科院分区：
文献类型：
--
作者：
Makino, Y;Hosoda, H;Kawarabayashi, T
Ghrelin是生长激素促分泌剂的内源性配体，最初从大鼠胃中分离出来。它能刺激原代培养的脑垂体细胞释放生长激素。本文测定了16例非妊娠妇女、18例正常妊娠妇女、20例妊娠高血压综合征患者和10例产后妇女的血浆Ghrelin多肽浓度。非孕妇女血浆Ghrelin浓度为239.5+/-16.9fmol/mL。正常妊娠晚期血浆Ghrelin浓度为127.1+/-5.6fmol/mL。正常孕妇血浆Ghrelin浓度与全身血压呈负相关(收缩压r=-0.564，P<0.05；舒张压r=-0.610，P<0.01)。妊娠高血压综合征孕妇的Ghrelin水平也显著高于正常孕妇(177.9+/-14.6fmol/m L，P<；0.05)。此外，血浆Ghrelin水平与全身血压显著相关(收缩压：r=-0.482，P<0.05；舒张压：r=-0.466，P<；0.05)。这些结果首次表明，Ghrelin可能在正常妊娠期间的心血管控制和妊娠期间的病理生理条件(如妊娠高血压综合征)中发挥一定的作用。
Ghrelin, an endogenous ligand for the growth hormone secretagogues, was originally isolated from rat stomach. It stimulates the release of growth hormone from primary pituitary cell cultures. We investigated the plasma concentration of ghrelin peptide in 16 nonpregnant women, 18 normal pregnant women, 20 patients with pregnancy-induced hypertension, and 10 postpartum women. The plasma concentration of ghrelin in nonpregnant women was 239.5 +/- 16.9 fmol/mL. The plasma concentration of ghrelin in normal pregnant women at the third trimester was 127.1 +/- 5.6 fmol/mL. There was negative correlation between plasma ghrelin concentration and systemic blood pressure in normal pregnant women (systolic: r = -0.564, P < 0.05; diastolic: r = -0.610, P < 0.01). Pregnant women with pregnancy-induced hypertension (177.9 +/- 14.6 fmol/mL, P < 0.05) also had significantly higher levels of ghrelin compared with those of normal pregnant women. In addition, there was a significant correlation between plasma ghrelin levels and systemic blood pressure (systolic: r = -0.482, P < 0.05; diastolic: r = -0.466, P < 0.05). These results suggest for the first time that ghrelin might have some role in cardiovascular control during normal pregnancy and in pathophysiological conditions in pregnancy, such as pregnancy-induced hypertension.