Higher blood pressure predicts lower regional grey matter volume: Consequences on short-term information processing
Higher blood pressure predicts lower regional grey matter volume: Consequences on short-term information processing
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DOI：
10.1016/j.neuroimage.2006.01.003
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发表时间：
2006-06-01
期刊：
影响因子：
5.7
通讯作者：
Jennings, J. Richard
中科院分区：
文献类型：
--
作者：
Gianaros, Peter J.;Greer, Phil J.;Jennings, J. Richard
高血压是弥漫性脑萎缩的危险因素。然而，几乎没有证据表明，较高的血压预示着局灶性脑萎缩，正如区域脑组织体积较低所表明的那样。这项基于体素的形态计量学研究测试了(A)较高的血压是否预示着较低的区域灰质或白质体积，以及(B)与血压相关的区域脑组织体积的减少是否预示着较差的神经心理测试表现。受试者为76名男性(男性年龄61.33岁，SD=4.95岁)和58名女性(男性年龄59.86岁，SD=5.10岁)，无心脑血管或神经精神疾病。结果显示，在男性中，较高的静息收缩压预示着辅助运动区及邻近的额叶上回、扣带回前皮质和颞中回的灰质体积较低。在男性中，辅助运动区的灰质体积较小，也预示着完成执行控制的连线B部分测试的时间较慢，对工作记忆的四个单词的短期记忆测试中的项目回忆能力较差。这些关系与年龄、脑组织总体积、教育历史、颈动脉粥样硬化的严重程度以及脑室周围和皮质下白质病变的程度无关。在女性中，血压、局部脑组织体积和认知功能之间没有统计上的显著关系。这些发现表明，男性血压较高，区域灰质体积较低，认知功能较差，而认知功能较差，独立于其他风险因素和令人困惑的医疗条件，这之间存在功能关系。(C)2006 Elsevier Inc.保留所有权利。
Hypertension is a risk factor for diffuse brain atrophy. Yet, there is little evidence that higher blood pressure predicts focal brain atrophy, as indicated by a lower volume of regional brain tissue. This voxel-based morphometry study tested (a) whether higher blood pressure predicts lower regional grey or white matter volume and (b) whether a blood-pressure-related reduction in regional brain tissue volume predicts poorer neuropsychological test performance. Participants were 76 men (M age = 61.33, SD = 4.95 years) and 58 women (M age = 59.86, SD = 5.10 years) without a cardiovascular, cerebrovascular, or neuropsychiatric disease. Results showed that among men, higher resting systolic blood pressure predicted lower grey matter volume in the supplementary motor area and adjacent superior frontal gyrus, the anterior cingulate cortex, and middle temporal gyros. Among men, lower grey matter volume in the supplementary motor area also predicted a slower time to complete the Trail Making Part B Test of executive control and a poorer recall of items from the Four-word Short-term Memory Test of working memory. These relationships were independent of age, total brain tissue volume, educational history, severity of carotid atherosclerosis, and the extent of periventricular and subcortical white matter lesions. Among women, no statistically significant relationships were found between blood pressure, regional brain tissue volume, and cognitive function. These findings suggest a functional relationship among men between higher blood pressure, lower regional grey matter volume, and poorer cognitive function that is independent of other risk factors and confounding medical conditions. (c) 2006 Elsevier Inc. All rights reserved.