EEG-fMRI in focal epilepsy: Local activation and regional networks
EEG-fMRI in focal epilepsy: Local activation and regional networks
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DOI：
10.1016/j.clinph.2013.06.182
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发表时间：
2014-01-01
影响因子：
4.7
通讯作者：
Jackson, G. D.
中科院分区：
文献类型：
--
作者：
Flanagan, D.;Badawy, R. A. B.;Jackson, G. D.
目的：为了确定特点BOLD信号变化与发作间期癫痫样放电（IEDs）在一个异质性组的局灶性epilepsy patients.Methods：EEG/fMRI研究27局灶性epilepsy患者进行了审查，注意的程度和位置的IED和由此产生的模式BOLD信号的变化。结果：fMRI结果为个体患者提供了新的临床信息。我们确定了一个显着的共同节点内同侧梨状皮质以及模式涉及遥远的皮质或皮质下areas.Conclusion：尽管IED局灶性癫痫的异质性，有重要的共同特点underpining IED与一个高度显着的功能磁共振成像节点在同侧梨状皮质。在具有异质性致痫灶的患者中，IED所涉及的网络具有重要的共同特征。我们证实梨状皮质是局灶性癫痫患者IED的共同节点，因此提供了进一步研究和潜在治疗的靶点。我们描述了BOLD信号变化的重要特征，伴随着局灶性和弥漫性IED，这将有助于研究人员和临床医生导航这些研究揭示的有时复杂的结果。(C)2013年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To identify features of BOLD signal change associated with interictal epileptiform discharges (IEDs) in a heterogeneous group of focal epilepsy patients.Methods: EEG/fMRI studies in 27 focal epilepsy patients were reviewed with attention given to the extent and location of the IED and the resulting pattern of BOLD signal change. Second order group analysis was used to identify common features.Results: fMRI results provided novel clinical information for individual patients. We identified a significant common node within the ipsilateral piriform cortex as well as patterns involving distant cortical or subcortical areas.Conclusion: Despite the heterogeneity of IEDs in focal epilepsy, there are important common features underpining IEDs with a highly significant fMRI node in the ipsilateral piriform cortex.Significance: There are important common features in the networks involved in IEDs in patients with a heterogeneous range of epileptogenic foci. We confirm that the piriform cortex is a common node underlying IEDs in patients with focal epilepsy and so provides a target for further study and potential therapy. We describe important features of BOLD signal change that accompany focal and diffuse IEDs that will help researchers and clinicians navigate the sometimes complex findings revealed by these studies. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.