Rewiring of Developing Spinal Nociceptive Circuits by Neonatal Injury and Its Implications for Pediatric Chronic Pain.
Rewiring of Developing Spinal Nociceptive Circuits by Neonatal Injury and Its Implications for Pediatric Chronic Pain.
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DOI：
10.3390/children3030016
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发表时间：
2016-09-20
期刊：
影响因子：
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通讯作者：
Baccei ML
中科院分区：
文献类型：
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作者：
Baccei ML
现在有大量证据表明，新生儿组织损伤可以引起疼痛敏感性的长期变化，但潜在的细胞和分子机制仍不清楚。这篇综述强调了我们对早期生命关键时期损伤如何调节脊髓浅层背角（SDH）突触网络功能组织的理解的最新进展，这种方式有利于过度放大向大脑的上行伤害性信号，这可能有助于儿童慢性疼痛的产生和/或维持。SDH内突触功能的这些持续改变也可能有助于通过新生儿组织损伤形成疼痛通路的充分记录的“启动”。
Significant evidence now suggests that neonatal tissue damage can evoke long-lasting changes in pain sensitivity, but the underlying cellular and molecular mechanisms remain unclear. This review highlights recent advances in our understanding of how injuries during a critical period of early life modulate the functional organization of synaptic networks in the superficial dorsal horn (SDH) of the spinal cord in a manner that favors the excessive amplification of ascending nociceptive signaling to the brain, which likely contributes to the generation and/or maintenance of pediatric chronic pain. These persistent alterations in synaptic function within the SDH may also contribute to the well-documented “priming” of developing pain pathways by neonatal tissue injury.