Novel pyrroles from the Oregon red alga Gracilariopsis lemaneiformis.
Novel pyrroles from the Oregon red alga Gracilariopsis lemaneiformis.
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来自俄勒冈州红藻 Gracilariopsis lemaneiformis 的新型吡咯。
DOI：
10.1021/np50074a009
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发表时间：
1991
影响因子：
5.1
通讯作者：
Gerwick,WH
中科院分区：
文献类型：
--
作者：
Jiang,ZD;Gerwick,WH
从温水红藻中分离出两个新的吡咯类天然产物，作为二乙酸衍生物。通过光谱方法（主要是高场核磁共振和质谱）确定了这些c -和N-（2-乙酰氧基）-丙基-2-（2-乙酰氧基）-乙酰吡啶[2]和N-（2-乙酰氧基）-乙基-2-（2-乙酰氧基）-乙酰吡啶[2]的结构。在过去的几年里，我们对来自美国太平洋西北部的寒水和温带水藻类的天然产物化学的探索表明，许多产生多不饱和脂肪酸来源的代谢物（1-5）。除了四吡咯色素外，含吡咯的天然产物在海洋环境中很少遇到，主要分布于海绵（6,7）、苔藓虫(8)、蓝藻和褐藻(6)。因此，我们被鼓励确定俄勒冈红藻中两种吡咯天然产物的结构，Gracilariopsis lemaneiformis (Bory) Dawson, Acleto et Foldvik (Gracilariaceae)，尽管
Two new pyrrole natural products have been isolatedfrom the temperate-water red alga, Gracilariopsis lemaneiformis, as diacetate derivatives. The structures of these C-and N-alkylated pyrroles were determined by spectroscopic methods (principally high field nmr and ms) to be N-(2-acetoxy)-propyl-2-(2-acetoxy)-acetopyrrole [2] and N-(2-acetoxy)-ethyl-2-(2-acetoxy)-acetopyrrole [4], Over thepast few years, our exploration of the natural product chemistry of coldand temperate-water algae from thePacific Northwest of the United States has revealed that manyproduce metabolites of polyunsaturated fatty acid origin (1—5). Other than tetrapyrrole pigments, pyrrole-containing natural products have been encountered only rarely in the marine environment, with distributionlimited principally to sponges (6, 7), bryozoans (8), cyanobacteria, and brown algae (6). Hence, we were encouraged to define the structures of two pyrrole natural products from the Oregon red alga, Gracilariopsis lemaneiformis (Bory) Dawson, Acleto et Foldvik (Gracilariaceae), despite