Endosymbiosis: The feeling is not mutual
Endosymbiosis: The feeling is not mutual
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DOI：
10.1016/j.jtbi.2017.06.008
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发表时间：
2017-12-07
影响因子：
2
通讯作者：
McCutcheon, John P.
中科院分区：
文献类型：
--
作者：
Keeling, Patrick J.;McCutcheon, John P.
内共生是一种对真核生物细胞器起源提供了显著解释力的观点。但它也提出了一些假设，这些假设也很有影响力，但没有得到充分的检验。下面我们来看看其中的两个，看看它们是否符合目前的证据。我们首先提出的假设是，内共生关系，如营养共生和真核细胞器是相互关系。相反，我们认为它们是更片面的联系，可以被视为与环境相关的权力斗争，就像任何其他生态相互作用一样。第二个假设是，在内共生相互作用过程中（如细胞器的起源），宿主基因组将从宿主系统中承担功能的内共生体中获得大量基因（与充分记录的基因相反，其产物只是针对内共生体或细胞器）。这些基因大量存在的想法影响了许多关于细胞器进化和分布的假设，但在最仔细检查的系统中，没有明显的基因大规模迁移。总的来说，我们认为内共生的性质和影响都需要不断重新评估，以充分了解它在细胞生物学和进化中真正发挥的作用。(C) 2017 Elsevier Ltd.版权所有。
Endosymbiosis is an idea that provided a remarkable amount of explanatory power about the origins of eukaryotic organelles. But it also promoted a number of assumptions that have also been influential, but are less well-examined. Here we look at two of these to see whether or not they fit current evidence. The assumption we first address is that endosymbiotic relationships such as nutritional symbioses and eukaryotic organelles are mutualisms. We argue instead that they are more one-sided associations that can be regarded as context-dependent power struggles like any other ecological interaction. The second assumption is that during endosymbiotic interactions (such as the origin of organelles), the host genomes will acquire a great many genes from endosymbionts that assume functions in host systems (as opposed to the well-documented genes whose products are simply targeted back to the endosymbiont or organelle). The idea that these genes exist in large numbers has been influential in a number of hypotheses about organelle evolution and distribution, but in the most carefully-examined systems no such mass migration of genes is evident. Overall, we argue that both the nature and impact of endosymbiosis need to be constantly re-evaluated to fully understand what roles it really plays in both cell biology and evolution. (C) 2017 Elsevier Ltd. All rights reserved.